Table 3. Metabolite concentrations (mmol/kg_ww ± standard deviations) with statistical comparisons for a voxel in the thalamus.

	Thalamus
	HC	MDD	Schizophrenia	P(HC-MDD)	P(HC-Schizophrenia)	P(MDD-Schizophrenia)
Glu	7.4 (0.6)	7.8 (0.9)	7.4 (1.0)	0.161	0.493	0.173
Gln	1.3 (0.6)	1.5 (0.7)	1.9 (0.6)	0.309	0.009	0.072
Gly	0.9 (0.3)	0.9 (0.3)	0.7 (0.1)	0.906	0.017	0.012
Gsh	1.3 (0.3)	1.2 (0.2)	1.4 (0.3)	0.355	0.295	0.054
Tau	1.9 (0.5)	2.2 (0.6)	2.3 (0.4)	0.142	0.034	0.496
Asp	2.5 (1.4)	3.2 (1.8)	3.4 (1.9)	0.273	0.180	0.786
Myo	7.2 (0.8)	6.4 (1.2)	7.4 (1.0)	0.014	0.447	0.004
Scy	0.4 (0.1)	0.4 (0.1)	0.4 (0.1)	0.235	0.422	0.052
Asc	0.9 (0.7)	0.7 (0.5)	1.2 (0.5)	0.289	0.259	0.033
TCH	2.2 (0.2)	2.2 (0.2)	2.2 (0.2)	0.892	0.764	0.665
TCR	6.5 (0.8)	6.4 (0.9)	6.5 (0.8)	0.702	0.795	0.907
TNAA	11.1 (0.9)	11.0 (1.0)	10.8 (0.9)	0.722	0.465	0.703

HC, healthy controls; MDD, major depressive disorder; Glu, glutamate; Gln, glutamine; Gly, glycine; Gsh, glutathione; Tau, taurine; Asp, aspartate; Myo, myo-inositol; Scy, scyllo-inositol; Asc, ascorbate; TCH, total choline; TCR, total creatine; TNAA, total NAA. Bolded values indicate statistical signficance (alpha<0.05/3, one-tailed, for Gln; alpha<0.05/2, two-tailed, for Gly; alpha<0.05/2, one-tailed, for Myo).