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. 2017 Feb 2;7:41506. doi: 10.1038/srep41506

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Copyright © 2017, The Author(s)

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(a) Individual tumour volumes in the PDT group. Seven of eleven tumours regressed after PDT; in two animals (#8, 9, there was tumour growth arrest but no volume decrease, and in two other cases (#10, 11) tumour growth continued despite PDT (b) Monitoring of relative tumour volume changes for treated (n = 11), light only (n = 5) and untreated (n = 5) control groups. Data are shown as mean ± SD. Tumour growth was overall inhibited by PDT in the treatment group, showing pronounced volume decrease. *Statistically significant difference from light-only and untreated groups, p ≤ 0.05. Inset demonstrates distribution of eleven tumour volumes at 7 days post PDT. Despite strong (and statistically significant) overall decrease in tumour volumes in the PDT group, the distribution of individual tumour volumes revealed the presence of two moderate responders and two non-responders in this cohort; see text for a discussion on this finding.