Table 2.

Meta-data of genes shown in the cluster analysis whose mRNA expression correlated with the log₁₀IC₅₀ values of curcumin in the NCI tumor cell line panel.

Gene symbol	Gene acc no.	Gene name	Gene function
ABCA1	AI344681	ATP-binding cassette, sub-family A (ABC1), member 1	cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
AK2	U54645	Adenylate kinase 2	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.
ALDH3B1	U10868	Aldehyde dehydrogenase 3 family, member B1	Oxidizes medium and long chain saturated and unsaturated aldehydes. Protective role against the cytotoxicity induced by lipid peroxidation.
ANXA2P1	M62896	Annexin A2 pseudogene 1	Involved in cell proliferation and membrane physiology and is related to cancer progression.
BAIAP2	AB015020	BAI1-associated protein 2	Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins.
BAIAP2	AB015019	BAI1-associated protein 2	Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Participates in actin bundling, if associated with EPS8. Promoting filopodial protrusions.
BTFA1	AF038362	B-TFIID transcription factor-associated, 170kDa	Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box.
CAPN2	M23254	Calpain 2 (m/II) large subunit	Calcium-regulated non-lysosomal thiol-protease, which catalyzes proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
CHRNB4	U48861	Cholinergic receptor, nicotinic, beta 4	Leads to opening of an ion-conducting channel across the plasma membrane.
CRIM1	AI651806	Cysteine rich transmembrane BMP regulator 1 (chordin-like)	Role in capillary formation and maintenance during angiogenesis.
DDX39B	AC002400	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity.
DFFB	AF064019	DNA fragmentation factor, 40kDa, beta polypeptide	Induces DNA fragmentation and chromatin condensation during apoptosis.
DT-UP-PM	U38980	DTX2P1-UPK3BP1-PMS2P11	Encodes a putative E3-ubiquitin ligase with no known biological function.
DTX2	AI138834	Deltex 2	Regulator of Notch signaling.
EGFR	X00588	Epidermal growth factor receptor	Receptor tyrosine kinase activating several signaling cascades. Activates the NF-kappa-B signaling cascade.
EHD1	AF001434	EH-domain containing 1	Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
HNRNPR	AF000364	Heterogeneous nuclear ribonucleoprotein R	Component of ribonucleosomes, which are complexes of >20 other heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
IQCB1	D25278	IQ motif containing B1	Involved in ciliogenesis.
MTHFD2	X16396	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2	Encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
NFATC2IP	AA152202	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	In T-helper 2 (Th2) cells, regulates NFAT-driven transcription of cytokine genes IL3, IL4, IL5 and IL13. Recruits PRMT1 to the IL4 promoter and facilitates subsequent histone acetylation at the IL4 locus. Promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
NR2F2	M64497	Nuclear receptor subfamily 2	Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription.
PDK1	L42450	Pyruvate dehydrogenase kinase, isozyme 1	Role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. Role in cellular responses to hypoxia. Important for cell proliferation under hypoxia.
PLEKHM1	AB002354	Pleckstrin homology domain containing, family M (with RUN domain) member 1	Involved in vesicular transport in the osteoclast. Role in sialyl-lex-mediated transduction of apoptotic signals.
POLR2L	N24355	Polymerase (RNA) II (DNA directed) polypeptide L	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
PRPF4B	U48736	Pre-mRNA processing factor 4B	Role in pre-mRNA splicing. Phosphorylates SF2/ASF.
PSMG1	AJ006291	Proteasome (prosome, macropain) assembly chaperone 1	Chaperone protein, which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2.
RBBP4	X74262	Retinoblastoma binding protein 4	Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates.
RBMX2	AL050405	RNA binding motif protein, X-linked 2	Encodes RNA binding motif protein, X-linked 2.
RHOD	U61374	Ras homolog family member D	Involved in endosome dynamics. Coordinates membrane transport with the function of the cytoskeleton.
RPA2	J05249	Replication protein A2	Required for DNA recombination, repair and replication. Required for the recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.
SLC25A36	AL049246	Solute carrier family 25 (pyrimidine nucleotide carrier), member 36	To catalyze uptake of pyrimidine (deoxy) nucleotide triphosphates into the mitochondrial matrix in exchange for internal pyrimidine (deoxy) nucleotide monophosphates or (deoxy) nucleotide diphosphates.
SNRNP40	AF090988	Small nuclear ribonucleoprotein 40kDa	Component of the U5 small nuclear ribonucleoprotein (snRNP) complex.
SPEN	AL096858	Spen family transcriptional repressor	Serve as nuclear matrix platform that organizes transcriptional responses. Essential corepressor protein, which regulates different key pathways such as the Notch pathway. Represses transcription via the recruitment of large complexes containing histone deacetylase proteins.
SRSF4	LI4076	Serine/arginine-rich splicing factor 4	Role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
TAF12	X84002	TATA box binding protein (TBP)-associated factor	TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.
TGM2	M55153	Transglutaminase 2	Catalyzes the cross-linking of proteins and conjugation of polyamines to proteins.
TMEM115	U09584	Transmembrane protein 115	Role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum.
TOPBP1	D87448	Topoisomerase (DNA) II binding protein 1	Required for DNA replication. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage.
VPS41	U87309	Vacuolar protein sorting 41	Required for vacuolar assembly and vacuolar traffic.
WWC1	AB020676	WW and C2 domain containing 1	Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, which plays a role in tumor suppression by restricting proliferation and promoting apoptosis. Transcriptional coactivator of ESR1. Regulates collagen-stimulated activation of the ERK/MAPK cascade.

Gene information was taken from the OMIM database, National Cancer Institute, USA (http://www.ncbi.nlm.nih.gov/Omim/), and from the GeneCard database of the Weizman Institute of Science, Rehovot, Israel (http://bioinfo.weizmann.ac.il/cards/index.html).