Table 3.
Meta-data of genes shown in the cluster analysis of whose mRNA expression correlated with log10IC50-values of vitamin C in the NCI tumor cell line panel.
| Gene symbol | GenBank acc no. | Gene name | Gene function |
|---|---|---|---|
| ABCA1 | A1344681 | ATP-binding cassette, sub-family A (ABC1), member 1 | cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. |
| ARHGAP19 | U79256 | Rho GTPase activating protein 19 | GTPase activator for Rho-type GTPases. |
| CBFB | L20298 | Core-binding factor, beta subunit | CBF binds to enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and LCK, IL3, and GM-CSF promoters. |
| CD81 | M33680 | CD81 | Regulation of lymphoma cell growth. Involved in signal transduction. |
| CDK7 | X77743 | Cyclin-dependent kinase 7 | The catalytic subunit of the CDK-activating kinase (CAK) complex. |
| CRADD | U84388 | CASP2 and RIPK1 domain containing adaptor with death domain | Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. |
| DBH | X13255 | Dopamine beta-hydroxylase (dopamine beta-monooxygenase) | Conversion of dopamine to noradrenaline. |
| DIMT1 | AF091078 | DIM1 dimethyladenosine transferase | Dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3′-end of 18S rRNA in the 40S particle |
| EED | AF080227 | Embryonic ectoderm development | Transcriptional repression of target genes. Constituent of a recruiting platform for DNA methyltransferases, thereby involved in epigenetic repression. |
| FOXG1 | X74143 | Forkhead box G1 | Transcription repression factor. |
| GRN | AF055008 | Granulin | Cytokine-like activity. Role in inflammation, wound repair, and tissue remodeling. |
| HDLBP | M64098 | High density lipoprotein binding protein | Role in cell sterol metabolism. Protects cells from over-accumulation of cholesterol. |
| HMGN1 | J02621 | High mobility group nucleosome binding domain 1 | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer which maintains transcribable genes in a unique chromatin conformation. |
| HNRNPR | AF000364 | Heterogeneous nuclear ribonucleoprotein R | Component of ribonucleosomes, which are complexes of >20 other heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. |
| HPRT1 | M31642 | Hypoxanthine phosphoribosyltransferase 1 | Transfers 5-phosphoribosyl from 5-phosphoribosylpyrophosphate onto purine. Generation of purine nucleotides through the purine salvage pathway. |
| KLHL35 | AA471042 | Kelch-like family member 35 | A protein coding gene. |
| KNG1 | K02566 | Kininogen 1 | Role in blood coagulation. Inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. |
| LRP10 | AL080164 | Low density lipoprotein receptor-related protein 10 | Receptor involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver. |
| MAP2K2 | L11285 | Mitogen-activated protein kinase kinase 2 | Catalyzes the concomitant phosphorylation of threonine and tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases. |
| MEGF8 | AB011541 | Multiple EGF-like-domains 8 | Encodes a single pass membrane protein which participates in developmental regulation and cellular communication |
| NUP160 | D83781 | Nucleoporin 160 kDa | Involved in poly (A)+ RNA transport. |
| PCMT1 | D25547 | Protein-L-isoaspartate (D-aspartate) O-methyltransferase | Catalyzes methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins repair and/or degradation of damaged proteins. |
| PLA2R1 | U17034 | Phospholipase A2 receptor 1 | Receptor for secretory phospholipase A2. Activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. Involved in responses in proinflammatory cytokine productions during endotoxic shock. |
| PLAUR | X74039 | Plasminogen activator, urokinase receptor | Role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of uPA. |
| PNN | U77718 | Pinin, desmosome associated protein | Transcriptional activator of the E-cadherin gene. Regulation of alternative pre-mRNA splicing. Regulates specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. |
| PNPLA6 | AJ004832 | Patatin-like phospholipase domain containing 6 | Deacylation of intracellular phosphatidylcholine generating glycerophosphocholine. |
| PPWD1 | D38552 | Peptidylprolyl isomerase domain and WD repeat containing 1 | Accelerates the folding of proteins. Involved in pre-mRNA splicing. |
| PSAP | J03077 | Prosaposin | Stimulates the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Behaves as a myelinotrophic and neurotrophic factor. |
| RABAC1 | AJ133534 | Rab acceptor 1 | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion. |
| RGS13 | AF030107 | Regulator of G-protein signaling 13 | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. |
| SETD4 | AB004848 | SET domain containing 4 | Role in protein encoding. |
| SI | X63597 | Sucrase-isomaltase (alpha-glucosidase) | Role in the final stage of carbohydrate digestion. |
| SLC7A2 | D29990 | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | Transport of cationic amino acids (arginine, lysine and ornithine). Regulatory role in activation of macrophages. |
| SMA4 | X83300 | Glucoridase | Required for signal transduction and it also defines a conserved family of transforming growth factor beta pathway components. |
| TAF9 | U21858 | TATA box binding protein (TBP)-associated factor | Gene regulation associated with apoptosis. Regulation of RNA polymerase II-mediated transcription. |
| TCERG1 | AF017789 | Transcription elongation regulator 1 | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters in a TATA box-dependent manner. |
| TFAM | M62810 | transcription factor A | Mitochondrial transcription regulation. |
| Maintenance of normal levels of mitochondrial DNA. Organizing and compacting mitochondrial DNA. | |||
| TOM1 | AJ006973 | Target of myb1 | Involved in intracellular trafficking. Probable association with membranes. |
| UBE2N | D83004 | Ubiquitin-conjugating enzyme E2N | The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical “Lys-63”-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. |
| ZNF195 | AF003540 | Zinc finger protein 195 | May be involved in transcriptional regulation. |
Gene information was taken from the OMIM database, National Cancer Institute, USA (http://www.ncbi.nlm.nih.gov/Omim/), and from the GeneCard database of the Weizman Institute of Science, Rehovot, Israel (http://bioinfo.weizmann.ac.il/cards/index.html).