Table 4.
Separation of clusters of NCI cell lines obtained by hierarchical cluster analyses for curcumin (Figure 6) or ascorbic acid (Figure 7).
| Sensitive | Resistant | |
|---|---|---|
| CURCUMIN | ||
| Partition | <–5.1 M | ≥−5.1 M |
| Cluster1 | 0 | 4 |
| Cluster2 | 5 | 11 |
| Cluster3 | 16 | 3 |
| Cluster4 | 10 | 8 |
| Cluster5 | 1 | 1 |
| Chi-square test | P = 4.59 * 10−3 | |
| ASCORBIC ACID | ||
| Partition | <−2.7 M | ≥−2.7 M |
| Cluster 1 | 2 | 0 |
| Cluster 2 | 5 | 14 |
| Cluster 3 | 12 | 20 |
| Cluster 4 | 0 | 6 |
| Chi-square | P = 0.050 | |
The median log10IC50-values (–5.1 M for curcumin and –2.7 M for ascorbic acid) were used as cut-off to separate tumor cell lines as being “sensitive” or “resistant.”