Table 3. Risk of Cardiovascular Event Predicted by Model of Established Risk Factors and New Model* in the Diabetic Cohort from the Singapore Malay Eye Study.
|
+‘New’ Risk Category |
Reclassified to Higher risk | Reclassified to Lower risk | NRI, % | P-value | ||||
|---|---|---|---|---|---|---|---|---|
| Low | Intermediate | High | Total | |||||
| Subjects with incident CVD event | ||||||||
| *Established Risk Category | 12 | 9 | 3.49 | 0.512 | ||||
| Low | 7 | 1 | 0 | 8 | ||||
| Intermediate | 2 | 10 | 11 | 23 | ||||
| High | 0 | 7 | 48 | 55 | ||||
| Total | 9 | 18 | 59 | 86 | ||||
| Subjects with no incident CVD event | ||||||||
| *Established Risk Category | 62 | 146 | 13.48 | <0.001 | ||||
| Low | 179 | 26 | 5 | 210 | ||||
| Intermediate | 89 | 104 | 31 | 224 | ||||
| High | 1 | 56 | 132 | 189 | ||||
| Total | 269 | 186 | 168 | 623 | ||||
| NRI, % | 16.97 | 0.004 | ||||||
+Established risk factors include age (years), gender (male, female), HbA1c, systolic blood pressure (mmHg), total cholesterol (mmol/L), HDL cholesterol (mmol/L), current smoking (yes, no), diabetic medication (yes, no) and duration of diabetes (years).
*New risk factors include established risk factors, serum biomarkers (eGFR and hsCRP) and retinal microvascular parameters (retinal arteriolar caliber, retinal venular caliber, retinal vascular fractal dimension and presence of retinopathy).
NRI: Net reclassification improvement.
Risk Categories %.
Low 0− < 6.35.
Intermediate 6.35–13.2.
High >13.2.