Table 1.
Demographic and clinical characteristics of the MCI-DEM and cognitively stable (CS) groups.
| PRODE data set | MCI-DEM | CS | Test statistics | p-value∗ |
|---|---|---|---|---|
| N | 29 | 40 | – | – |
| Age – mean (SD) | 78.1 (7,3) | 76,4 (5,8) | t = -1.5 | 0.31 |
| Sex – n women (%) | 22 (75%) | 29 (72%) | χ2 = 0.03 | 0.85 |
| Education (total years) – mean (SD) | 8.9 (2.79) | 10.1 (2.61) | t = -1.8 | 0,07 |
| Number of depressive episodes – (range) | 2.5 (0–4) | 1.5 (0–4) | z = -1.06 | 0.28 |
| Age at depression onset – median (range) | 29.7 (15–85) | 35.0 (16–88) | z = -1.02 | 0.3 |
| MADRS-1 – median (range) | 26 (15–52) | 27 (0–48) | z = -0.66 | 0.5 |
| MADRS-2 | 9 (0–31) | 7 (0–30) | z = -0.44 | 0.65 |
| MADRS-3 | 8 (0–35) | 4.5 (0–30) | z = -0.43 | 0.66 |
| MMSE-1 – mean (SD) | 24.6 (3.0) | 26.4 (1,8) | t = -2.71 | 0.005 |
| MMSE-2 | 25 (2.8) | 27 (1.9) | t = -5.42 | 0.009 |
| MMSE-3 | 23.8 (5.6) | 28 (1.7) | t = -5.90 | <0.001 |
MCI-DEM – LLD patients who received diagnosis of mild cognitive impairment or dementia at 1-year follow-up assessment. CS – LLD patients who remain cognitively stable at 1-year follow-up assessment.
∗t-test, Mann–Whitney U test or chi-square test as appropriate.
MADRS, Montgomery–Asberg Depression Rating Scale; MMSE, Mini Mental State Examination.
MADRS/MMSE – 1 - at inclusion, 2- at discharge, 3- after 1 year follow-up period.