Table 2. Association between Ki67 labeling index and clinicopathological findings.
| Ki67 labeling index | <5% (1) | 5–10% (2) | >10% (3) | p-value (1 vs 2) | p-value (2 vs 3) | p-value (1 vs 3) | |
|---|---|---|---|---|---|---|---|
| Number of cases | 304 (77.0%) | 68 (17.2%) | 23 (5.8%) | ||||
| Age (mean ± s.d.) | 51.2 ± 15.2 | 48.7 ± 17.4 | 52.5 ± 19.5 | 0.622a | 0.793a | 0.985a | |
| Sex (F/M, % male) | 255/47 (15.5%) | 61/7 (10.3%) | 18/5 (21.7%) | nsb | nsb | nsb | |
| Tumor size (mean ± s.d.) | 20.8 ± 12.7 | 22.9 ± 13.1 | 29.5 ± 20.1 | 0.548a | 0.380a | 0.144a | |
| LN metastasis | 190/303 (62.7%) | 43/68 (63.2%) | 16/23 (69.6%) | nsb | nsb | nsb | |
| Distant metastasisd | 3 (1.0%) | 1 (1.5%) | 2 (8.7%) | nsb | nsb | nsb | |
| Stagec | nsb | nsb | nsb | ||||
| I | 128 | 35 | 9 | ||||
| II | 8 | 0 | 0 | ||||
| III | 115 | 23 | 5 | ||||
| IV | 53 | 10 | 9 | ||||
| Ex | 212 (69.7%) | 56 (82.4%) | 17 (73.9%) | nsb | nsb | nsb | |
ns: not significant, p ≥ 0.05.
aNon-parametric ANOVA with Dunnett post hoc test.
bMultiple comparison test for proportions (using the COMPROP procedure in SAS http://www2.sas.com/proceedings/sugi31/204-31.pdf).
cCalculations for Stage (I + II) vs. (III + IV).
dAll metastatic sites were the lung.