Table 2. Association of miR-27a rs895819 polymorphism with the risk of atrophy gastritis and gastric cancer stratified by host characteristics.
| Variables | Genotype | AG vs CON | OR (95% CI) | P | GC vs CON | OR (95% CI) | P |
|---|---|---|---|---|---|---|---|
| Gendera | n = 1067 vs 1166 | n = 939 vs 1033 | |||||
| Male | AA | 343/377 | 1 (Ref) | 334/377 | 1 (Ref) | ||
| AG | 238/255 | 0.97 (0.76–1.23) | 0.803 | 268/255 | 1.15 (0.92–1.45) | 0.227 | |
| GG | 33/38 | 0.93 (0.56–1.55) | 0.787 | 33/38 | 0.96 (0.58–1.58) | 0.875 | |
| AG + GG VS. AA | 1.00 (0.77–1.22) | 0.772 | 1.13 (0.90–1.41) | 0.282 | |||
| GG VS. AG + AA | 0.95 (0.57–1.56) | 0.829 | 0.89 (0.55–1.46) | 0.648 | |||
| Female | AA | 234/276 | 1 (Ref) | 146/205 | 1 (Ref) | ||
| AG | 181/196 | 1.12 (0.84–1.47) | 0.443 | 140/138 | 1.44 (1.03–2.00) | 0.032 | |
| GG | 38/24 | 1.86 (1.06–3.27) | 0.030 | 18/20 | 1.17 (0.58–2.36) | 0.661 | |
| AG + GG VS. AA | 1.20 (0.92–1.56) | 0.183 | 1.39 (1.01–1.91) | 0.045 | |||
| GG VS. AG + AA | 1.77 (1.03–3.06) | 0.040 | 0.98 (0.50–1.95) | 0.959 | |||
| Agea | n = 1067 vs 1166 | n = 939 vs 1033 | |||||
| ≤60 | AA | 406/477 | 1 (Ref) | 334/406 | 1 (Ref) | ||
| AG | 283/324 | 1.02 (0.82–1.26) | 0.886 | 232/266 | 1.06 (0.84–1.33) | 0.655 | |
| GG | 46/39 | 1.39 (0.87–2.21) | 0.168 | 32/35 | 1.02 (0.61–1.70) | 0.948 | |
| AG + GG VS. AA | 1.06 (0.86–1.30) | 0.609 | 1.05 (0.84–1.32) | 0.667 | |||
| GG VS. AG + AA | 1.37 (0.87–2.16) | 0.173 | 1.01 (0.61–1.66) | 0.983 | |||
| >60 | AA | 171/176 | 1 (Ref) | 146/176 | 1 (Ref) | ||
| AG | 136/127 | 1.07 (0.76–1.49) | 0.712 | 176/127 | 1.74 (1.25–2.42) | 0.001 | |
| GG | 25/23 | 1.14 (0.61–2.14) | 0.682 | 19/23 | 1.10 (0.56–2.14) | 0.785 | |
| AG + GG VS. AA | 1.08 (0.78–1.48) | 0.659 | 1.63 (1.18–2.24) | 0.003 | |||
| GG VS. AG + AA | 1.11 (0.60–2.07) | 0.731 | 0.85 (0.44–1.62) | 0.614 | |||
| H. pylorib | n = 1067 vs 1166 | n = 939 vs 1033 | |||||
| negative | AA | 250/469 | 1 (Ref) | 240/165 | 1 (Ref) | ||
| AG | 179/315 | 1.06 (0.84–1.35) | 0.629 | 204/117 | 1.27 (1.00–1.62) | 0.055 | |
| GG | 36/41 | 1.62 (1.01–2.60) | 0.047 | 27/19 | 1.08 (0.63–1.85) | 0.782 | |
| AG + GG VS. AA | 1.12 (0.89–1.41) | 0.319 | 1.24 (0.98–1.57) | 0.069 | |||
| GG VS. AG + AA | 1.58 (0.99–2.51) | 0.054 | 0.94 (0.55–1.58) | 0.803 | |||
| positive | AA | 327/184 | 1 (Ref) | 240/417 | 1 (Ref) | ||
| AG | 240/136 | 0.98 (0.74–1.30) | 0.899 | 204/276 | 1.19 (0.88–1.61) | 0.262 | |
| GG | 35/21 | 0.92 (0.52–1.64) | 0.785 | 24/39 | 0.98 (0.52–1.82) | 0.936 | |
| AG + GG VS. AA | 0.97 (0.74–1.27) | 0.820 | 1.15 (0.86–1.55) | 0.335 | |||
| GG VS. AG + AA | 0.93 (0.53–1.64) | 0.810 | 0.90 (0.49–1.64) | 0.720 | |||
| Smokingb | n = 548 vs 586 | n = 333 vs 500 | |||||
| Never smoker | AA | 204/224 | 1 (Ref) | 102/180 | 1 (Ref) | ||
| AG | 143/142 | 1.08 (0.78–1.50) | 0.642 | 69/105 | 1.17 (0.78–1.77) | 0.444 | |
| GG | 26/18 | 1.95 (0.99–3.85) | 0.055 | 14/16 | 1.64 (0.74–3.67) | 0.225 | |
| AG + GG VS. AA | 1.17 (0.85–1.60) | 0.330 | 1.23 (0.83–1.82) | 0.295 | |||
| GG VS. AG + AA | 1.87 (0.96–3.64) | 0.066 | 1.53 (0.70–3.34) | 0.288 | |||
| Ever smoker | AA | 94/109 | 1 (Ref) | 74/107 | 1 (Ref) | ||
| AG | 68/82 | 0.95 (0.60–1.50) | 0.828 | 68/81 | 1.13 (0.71–1.82) | 0.606 | |
| GG | 11/11 | 1.21 (0.48–3.09) | 0.685 | 6/11 | 0.60 (0.20–1.84) | 0.376 | |
| AG + GG VS. AA | 0.98 (0.64–1.52) | 0.936 | 1.06 (0.67–1.67) | 0.819 | |||
| GG VS. AG + AA | 1.23 (0.50–3.07) | 0.653 | 0.54 (0.18–1.64) | 0.277 | |||
| Alcohol drinkingb | n = 547 vs 585 | n = 296 vs 499 | |||||
| Nondrinker | AA | 239/256 | 1 (Ref) | 105/211 | 1 (Ref) | ||
| AG | 157/165 | 1.07 (0.78–1.46) | 0.687 | 71/127 | 1.10 (0.74–1.64) | 0.641 | |
| GG | 27/17 | 2.08 (1.04–4.16) | 0.037 | 13/15 | 1.43 (0.62–3.33) | 0.406 | |
| AG + GG VS. AA | 1.15 (0.85–1.55) | 0.358 | 1.13 (0.77–1.66) | 0.521 | |||
| GG VS. AG + AA | 1.99 (1.01–3.90) | 0.047 | 1.35 (0.59–3.08) | 0.484 | |||
| Drinker | AA | 60/76 | 1 (Ref) | 52/75 | 1 (Ref) | ||
| AG | 53/60 | 0.99 (0.58–1.67) | 0.959 | 50/60 | 1.20 (0.70–2.06) | 0.503 | |
| GG | 11/11 | 1.22 (0.49–3.05) | 0.677 | 5/11 | 0.73 (0.23–2.30) | 0.587 | |
| AG + GG VS. AA | 1.03 (0.63–1.70) | 0.902 | 1.14 (0.68–1.93) | 0.620 | |||
| GG VS. AG + AA | 1.33 (0.54–3.27) | 0.542 | 0.71 (0.23–2.21) | 0.555 |
Note: aUsing Logistic Regession adusted by the other two factors of gender, age and H. pylori infection status. bUsing Logistic Regession adusted by gender, age and H. pylori infection status. CON:controls; AG: atrophic gastritis; GC:gastric cancer.