Table 3. The interaction of miR-27a rs895819 polymorphism and H. pylori infection statue in the risk of gastric cancer/atrophic gastritisa.
| Genotype | AG vs CON | GC vs CON | |||
|---|---|---|---|---|---|
| H. pylori | H. pylori | ||||
| (−) | (+) | (−) | (+) | ||
| AG + AA | Case/Control | 385/709 | 528/284 | 395/618 | 396/246 |
| OR (95%CI) | 1 (Ref) | 3.44 (2.84–4.16) | 1 (Ref) | 2.53 (2.07–3.10) | |
| GG | Case/Control | 80/116 | 74/57 | 73/114 | 75/55 |
| OR (95%CI) | 1.27 (0.93–1.73) | 2.38 (1.65–3.44) | 1.00 (0.73–1.38) | 2.13 (1.47–3.08) | |
| Pinteraction = 0.013 | Pinteraction = 0.505 | ||||
| OR (95%CI) = 0.54 (0.33–0.88) | OR (95%CI) = 0.84 (0.51–1.39) | ||||
Note: aP for interaction was used Logistic Regression adjusted by gender and age. CON: controls; AG: atrophic gastritis; GC: gastric cancer.