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. 2017 Feb 2;7:41439. doi: 10.1038/srep41439

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Copyright © 2017, The Author(s)

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(A) Representative synaptic GABA_ARs-mediated mIPSC traces in thalamic relay neurons in the control (normal saline, n = 16 cells), CFA-1D (n = 14 cells) and CFA-7D (n = 20 cells) groups. (B) Similar amplitudes of mIPSCs in three groups. (C) Compared with the control group, the frequency of mIPSCs remained unchanged in the CFA-1D group, but significantly increased in the CFA-7D group. (D) Representative IPSC pairs evoked by paired-pulse stimulations with a 50-ms interval in the control (n = 7 cells) and CFA-7D (chronic inflammatory pain, n = 9 cells) groups. (E) Increased paired-pulse ratios (PPRs = IPSC_2nd/IPSC_1st) induced by paired-pulse stimulation with 25-, 50-, 100- or 200-ms intervals in the CFA-7D group. Error bars indicated SEMs. *P < 0.05, **P < 0.01, one-way ANOVA with Tukey post-test for mIPSCs and two-way ANOVA with Bonferroni post-test for PPR analysis.