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. 2017 Feb 2;7:41439. doi: 10.1038/srep41439

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Histological illustration of microinjection sites at Bregma −2.8 mm. (B) Vehicle (normal saline) injection did not affect paw withdrawal latencies (PWLs). (C) Muscimol decreased PWLs in naïve and acute inflammatory pain rats (CFA-1D), but increased PWLs in chronic inflammatory pain rats (CFA-7D and CFA-14D). (D) Activation of extra-synaptic GABA_ARs with THIP had limited effects on PWLs in naïve or acute inflammatory pain rats (CFA-1D), but significantly attenuated thermal hyperalgesia in chronic inflammatory pain rats (CFA-7D and 14D). Error bars indicated SEMs, n = 10–12, *P < 0.05, **P < 0.01, ***P < 0.001, paired t tests.