Table 1.
Proteins mapped in the overlapping pathways of oxidative phosphorylation and mitochondrial dysfunction.
| Protein accession | Protein name | Protein symbol | Canonical pathway(s) |
|---|---|---|---|
| C2_18809 | Aconitase 2, mitochondrial | ACO2 | 1 |
| C2_6260 | Apoptosis-inducing factor 1, mitochondrial | AIFM1 | 1 |
| C2_1751 | ATP synthase subunit alpha, mitochondrial | ATP5A1 | 1,2 |
| C2_1973 | ATP synthase subunit beta, mitochondrial | ATP5B | 1,2 |
| C2_18579 | ATP synthase subunit gamma, mitochondrial | ATP5C1 | 1,2 |
| C2_6419 | ATP synthase subunit delta, mitochondrial | ATP5D | 1,2 |
| C2_24277 | ATP synthase subunit epsilon, mitochondrial | ATP5E | 1,2 |
| C2_176 | ATP synthase subunit b, mitochondrial | ATP5F1 | 1,2 |
| C2_958 | ATP synthase lipid-binding protein, mitochondrial | ATP5G1 | 1,2 |
| C2_6236 | ATP synthase subunit d, mitochondrial | ATP5H | 1,2 |
| C2_7051 | ATP synthase subunit e, mitochondrial | ATP5I | 1,2 |
| C2_1188 | ATP synthase subunit f, mitochondrial | ATP5J2 | 1,2 |
| C2_1627 | ATP synthase subunit g, mitochondrial | ATP5L | 1,2 |
| C2_123 | ATP synthase subunit O, mitochondrial | ATP5O | 1,2 |
| C2_3535 | Caspase 3 | CASP3 | 1 |
| C2_270 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | COX4I1 | 1,2 |
| C2_462 | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial | COX4I2 | 1,2 |
| C2_238 | Cytochrome c oxidase subunit 5A, mitochondrial | COX5A | 1,2 |
| C2_132 | Cytochrome c oxidase subunit 6A, mitochondrial | COX6A1 | 1,2 |
| C2_1197 | Cytochrome c oxidase subunit 6B1 | COX6B1 | 1,2 |
| C2_3512 | Cytochrome c oxidase subunit 7B, mitochondrial | COX7B | 1,2 |
| C2_4920 | Carnitine O-palmitoyltransferase 1, liver isoform | CPT1A | 1 |
| C2_568 | NADH-cytochrome b5 reductase 3 | CYB5R3 | 1 |
| C2_785 | Cytochrome c1, heme protein, mitochondrial | CYC1 | 1,2 |
| C2_198 | Mitochondrial fission 1 protein | FIS1 | 1 |
| C2_19719 | Glutathione reductase, mitochondrial | GSR | 1 |
| C2_1416 | 3-hydroxyacyl-CoA dehydratase 2 | HSD17B10 | 1 |
| C2_106937 | ATP synthase subunit a | MT-ATP6 | 1,2 |
| C2_5715 | Cytochrome c oxidase subunit 3 | MT-CO3 | 1,2 |
| C2_5958 | Nicastrin | NCSTN | 1 |
| C2_8082 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | NDUFA1 | 1,2 |
| C2_110117 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | NDUFA12 | 1,2 |
| C2_1985 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | NDUFA2 | 1,2 |
| C2_3631 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 | NDUFA4 | 1,2 |
| C2_9313 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | NDUFA6 | 1,2 |
| C2_332 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | NDUFA9 | 1,2 |
| C2_11239 | Acyl carrier protein, mitochondrial | NDUFAB1 | 1,2 |
| C2_497 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | NDUFB10 | 1,2 |
| C2_3428 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | NDUFB4 | 1,2 |
| C2_3928 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | NDUFB6 | 1,2 |
| C2_1170 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | NDUFB7 | 1,2 |
| C2_1488 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | NDUFS1 | 1,2 |
| C2_1740 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | NDUFS3 | 1,2 |
| C2_10276 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | NDUFS6 | 1,2 |
| C2_1860 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | NDUFS7 | 1,2 |
| C2_62722 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | NDUFS8 | 1,2 |
| C2_3103 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | NDUFV2 | 1,2 |
| C2_229 | Parkinson protein 7 | PARK7 | 1 |
| C2_2292 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | PDHA1 | 1 |
| C2_2010 | Peroxiredoxin 3 | PRDX3 | 1 |
| C2_4821 | Peroxiredoxin 5 | PRDX5 | 1 |
| C2_1571 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | SDHA | 1,2 |
| C2_791 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | SDHB | 1,2 |
| C2_1642 | Superoxide dismutase 2, mitochondrial | SOD2 | 1 |
| C2_1166 | Ubiquinol-cytochrome c reductase, complex III subunit X | UQCR10 | 1,2 |
| C2_516 | Ubiquinol-cytochrome c reductase binding protein | UQCRB | 1,2 |
| C2_507 | Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | UQCRFS1 | 1,2 |
| C2_2118 | Ubiquinol-cytochrome c reductase hinge protein | UQCRH | 1,2 |
| C2_12420 | Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | UQCRQ | 1,2 |
| C2_318 | Voltage-dependent anion-selective channel protein 1 | VDAC1 | 1 |
Canonical pathways are indicated by number: (1) Mitochondrial dysfunction; (2) Oxidative phosphorylation.