Table 3.
Proteins mapped in the overlapping pathways of protein synthesis, cellular assembly and remodeling and non-humoral immune response.
| Protein accession | Protein name | Protein symbol | Canonical pathway(s) |
|---|---|---|---|
| s_flp0005a11_f_1 | Alpha-2-macroglobulin | A2M | 6 |
| C2_2 | Actin, cytoplasmic 1 | ACTB | 5,7,9,10,12,14,15,16,17 |
| C2_1387 | Actin, alpha cardiac | ACTC1 | 5,7,9,10,12,14,15,16,17 |
| C2_102126 | Actin, cytoplasmic 2 | ACTG1 | 5,7,9,10,14,15,16,17 |
| C2_1801 | Alpha-actinin-3 | ACTN3 | 5,9,10,16 |
| C2_26557 | Alpha-actinin-4 | ACTN4 | 5,9,10,16 |
| C2_3453 | Actin-related protein 2-A | ACTR2 | 5,7,9,10,12,14,15,16,17 |
| C2_1771 | Actin-related protein 3 | ACTR3 | 5,7,9,10,12,14,15,16,17 |
| C2_5961 | Protein argonaute-2 | AGO2 | 8,13 |
| C2_17965 | Angiotensinogen | AGT | 6 |
| C2_22548 | Alpha-2-HS-glycoprotein | AHSG | 6 |
| C2_2100 | Protein AMBP | AMBP | 6 |
| C2_37278 | AP-1 complex subunit beta-1 | AP1B1 | 7 |
| C2_5784 | AP-2 complex subunit beta | AP2B1 | 7 |
| C2_1474 | AP-2 complex subunit mu-1-A | AP2M1 | 7 |
| C2_14608 | Serum amyloid P-component | APCS | 6 |
| C2_1042 | Apolipoprotein A-I | APOA1 | 6,7 |
| s_rl0001e11_f_1 | Apolipoprotein B-100 | APOB | 7 |
| C2_5591 | Apolipoprotein Eb | APOE | 7 |
| C2_487 | ADP-ribosylation factor 1-like 2 | ARF1 | 10 |
| C2_2038 | ADP-ribosylation factor 4 | ARF4 | 10 |
| C2_3418 | ADP-ribosylation factor 6 | ARF6 | 7,10,16 |
| C2_1604 | Rho GDP-dissociation inhibitor 1 | ARHGDIA | 12,15 |
| C2_22184 | Rho guanine nucleotide exchange factor 5 | ARHGEF5 | 15,17 |
| C2_18222 | Actin-related protein 2/3 complex subunit 1A | ARPC1A | 5,7,9,10,12,14,15,16,17 |
| C2_4212 | Actin-related protein 2/3 complex subunit 1B | ARPC1B | 5,7,9,10,12,14,15,16,17 |
| C2_22529 | Actin-related protein 2/3 complex subunit 2 | ARPC2 | 5,7,9,10,12,14,15,16,17 |
| C2_4166 | Actin-related protein 2/3 complex subunit 3 | ARPC3 | 5,7,9,10,12,14,15,16,17 |
| C2_427 | Actin-related protein 2/3 complex subunit 4 | ARPC4 | 5,7,9,10,12,14,15,16,17 |
| C2_503 | Actin-related protein 2/3 complex subunit 5 | ARPC5 | 5,7,9,10,12,14,15,16,17 |
| FM156976 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | ASAP1 | 10 |
| FP333165 | Complement C2 | C2 | 6 |
| C2_1398 | Complement C3 | C3 | 6 |
| s_flp0005d01_f_1 | Complement C5 | C5 | 6 |
| s_rl0001d01_f_1 | Complement component C9 | C9 | 6 |
| C2_15607 | Calpain-1 catalytic subunit | CAPN1 | 10 |
| C2_55335 | Calpain-5 | CAPN5 | 10 |
| C2_44459 | Calpain-8 | CAPN8 | 10 |
| C2_5497 | Calpain small subunit 1 | CAPNS1 | 10 |
| C2_9606 | CD2-associated protein | CD2AP | 7 |
| C2_16241 | Cdc42 effector protein 2 | CDC42EP2 | 14,17 |
| C2_2045 | Cadherin-1 | CDH1 | 9,15,16,17 |
| C2_11775 | Cadherin-2 | CDH2 | 9,15,17 |
| C2_9760 | Complement factor B | CFB | 6 |
| C2_1192 | Cofilin-2 | CFL2 | 5,14,15,17 |
| C2_1929 | Calcium-binding protein p22 | CHP1 | 7 |
| C2_9111 | CAP-Gly domain-containing linker protein 1 | CLIP1 | 9,16,17 |
| C2_39986 | Ceruloplasmin | CP | 6 |
| C2_540 | Casein kinase II subunit alpha | CSNK2A1 | 7 |
| C2_8203 | Casein kinase II subunit beta | CSNK2B | 7 |
| C2_13521 | Catenin alpha-2 | CTNNA2 | 9,16 |
| C2_23957 | Catenin delta-1 | CTNND1 | 9,16 |
| C2_33608 | Cytoplasmic FMR1-interacting protein 2 | CYFIP2 | 5 |
| C2_6275 | Dynamin-2 | DNM2 | 7,16 |
| C2_25618 | Eukaryotic translation initiation factor 1A, X-chromosomal | EIF1AX | 8,13 |
| C2_4011 | Eukaryotic translation initiation factor 2 subunit 1 | EIF2S1 | 8,13 |
| C2_5966 | Eukaryotic translation initiation factor 2 subunit 2 | EIF2S2 | 8,13 |
| C2_1614 | Eukaryotic translation initiation factor 2 subunit 3 | EIF2S3 | 8,13 |
| C2_533 | Eukaryotic translation initiation factor 3 subunit A | EIF3A | 8,11,13 |
| C2_630 | Eukaryotic translation initiation factor 3 subunit B | EIF3B | 8,11,13 |
| C2_114 | Eukaryotic translation initiation factor 3 subunit E | EIF3E | 8,11,13 |
| C2_92 | Eukaryotic translation initiation factor 3 subunit F | EIF3F | 8,11,13 |
| C2_1542 | Eukaryotic translation initiation factor 3 subunit G | EIF3G | 8,11,13 |
| C2_312 | Eukaryotic translation initiation factor 3 subunit I | EIF3I | 8,11,13 |
| C2_5501 | Eukaryotic translation initiation factor 3 subunit K | EIF3K | 8,11,13 |
| C2_372 | Eukaryotic translation initiation factor 3 subunit L | EIF3L | 8,11,13 |
| C2_68 | Eukaryotic translation initiation factor 3 subunit M | EIF3M | 8,11,13 |
| C2_406 | Eukaryotic initiation factor 4A-I | EIF4A1 | 8,11,13 |
| C2_746 | Eukaryotic initiation factor 4A-II | EIF4A2 | 8,11,13 |
| C2_1414 | Eukaryotic initiation factor 4A-III | EIF4A3 | 8,11,13 |
| C2_1810 | Eukaryotic translation initiation factor 4E | EIF4E | 8,11,13 |
| C2_2581 | Eukaryotic translation initiation factor 4E-binding protein 2 | EIF4EBP2 | 13 |
| C2_2506 | Eukaryotic translation initiation factor 4 gamma 1 | EIF4G1 | 8,11,13 |
| C2_31468 | Prothrombin | F2 | 5,6,7 |
| FP332283 | Fibrinogen beta chain | FGB | 6 |
| C2_38689 | Fibrinogen gamma chain | FGG | 6 |
| C2_49308 | Formin-binding protein 1 homolog | FNBP1 | 10,11,12,15,17 |
| C2_105435 | Ferritin light chain, oocyte isoform | FTL | 6 |
| C2_32560 | Rab GDP dissociation inhibitor alpha | GDI1 | 15 |
| C2_455 | Rab GDP dissociation inhibitor beta | GDI2 | 15 |
| C2_75053 | Guanine nucleotide-binding protein subunit alpha-11 | GNA11 | 15,17 |
| C2_5820 | Guanine nucleotide-binding protein subunit alpha-13 | GNA13 | 5,14,15,17 |
| C2_3738 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | GNAI1 | 15,17 |
| C2_6805 | Guanine nucleotide-binding protein G(k) subunit alpha | GNAI3 | 15,17 |
| C2_35672 | Guanine nucleotide-binding protein G(t) subunit alpha-2 | GNAT2 | 15,17 |
| C2_8162 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | GNB1 | 15,17 |
| C2_41327 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | GNB2 | 15,17 |
| C2_45 | Guanine nucleotide-binding protein subunit beta-2-like 1 | GNB2L1 | 15,17 |
| C2_3160 | Guanine nucleotide-binding protein subunit beta-4 | GNB4 | 15,17 |
| C2_64382 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | GNG12 | 1,15,17 |
| C2_7512 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | GNG2 | 15,17 |
| C2_4717 | Growth factor receptor-bound protein 2 | GRB2 | 5,6,7,8,10,13 |
| C2_265 | Gelsolin | GSN | 5,12 |
| C2_2149 | Heme oxygenase | HMOX1 | 6,11 |
| C2_61488 | Heterogeneous nuclear ribonucleoprotein K | HNRNPK | 6 |
| C2_27397 | Hemopexin | HPX | 6 |
| C2_4763 | Heat shock cognate 71 kDa protein | HSPA8 | 7 |
| C2_23533 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | IKBKE | 6 |
| C2_757 | Interleukin-6 receptor subunit alpha | IL6R | 6 |
| C2_5031 | Ras GTPase-activating-like protein IQGAP1 | IQGAP1 | 5,9,16,17 |
| C2_7014 | Ras GTPase-activating-like protein IQGAP2 | IQGAP2 | 5 |
| FP333792 | Inter-alpha-trypsin inhibitor heavy chain H2 | ITIH2 | 6 |
| C2_12615 | Inter-alpha-trypsin inhibitor heavy chain H3 | ITIH3 | 6 |
| C2_23019 | Junction plakoglobin | JUP | 9 |
| C2_29495 | Kininogen (Fragments) | KNG1 | 5 |
| C2_2112 | GTPase KRas | KRAS | 5,6,8,9,10,11,13 |
| C2_24867 | Dual specificity mitogen-activated protein kinase kinase 6 | MAP2K6 | 6 |
| C2_10488 | Mitogen-activated protein kinase 1 | MAPK1 | 5,6,8,10,11,13,17 |
| C2_15543 | Microtubule-associated protein RP/EB family member 1 | MAPRE1 | 16 |
| C2_86 | Moesin | MSN | 5,14,15,17 |
| C2_29145 | Myosin-11 | MYH11 | 5,9 |
| C2_14197 | Myosin-6 | MYH6 | 5,9 |
| C2_515 | Myosin-9 | MYH9 | 5,9 |
| C2_179 | Myosin light chain 1, skeletal muscle isoform | MYL1 | 5,9,12,14,15,17 |
| C2_2556 | Myosin light chain 3, skeletal muscle isoform | MYL3 | 5,9,12,14,15,17 |
| C2_3500 | Myosin light polypeptide 6 | MYL6 | 5,9,12,14,15,17 |
| C2_2090 | Myosin regulatory light polypeptide 9 | MYL9 | 5,9,10,12,14,15,17 |
| C2_2234 | Myosin regulatory light chain 2, smooth muscle minor isoform | MYLPF | 5,12,14,15,17 |
| C2_59686 | Myosin-Ie | MYO1E | 7 |
| C2_62194 | Myosin-VI | MYO6 | 7 |
| C2_82048 | Nuclear factor NF-kappa-B p105 subunit | NFKB1 | 6,17 |
| C2_24789 | Ephexin-1 | NGEF | 14 |
| C2_113264 | Nucleoside diphosphate kinase A1 | NME1 | 16 |
| C2_4961 | Glucocorticoid receptor | NR3C1 | 6 |
| C2_3168 | Polyadenylate-binding protein 1 | PABPC1 | 8,13 |
| C2_3226 | Serine/threonine-protein kinase PAK 2 | PAK2 | 5,10,12,15,17 |
| C2_2505 | 3-phosphoinositide-dependent protein kinase 1 | PDPK1 | 6,8,11,13 |
| C2_22976 | Profilin-1 | PFN1 | 5,12,14 |
| C2_4778 | 1-phosphatidylinositol-3-phosphate 5-kinase | PIKFYVE | 5,12,14,15,17 |
| C2_70006 | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 | PLCG1 | 10 |
| C2_4412 | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 | PLCG2 | 10 |
| C2_1167 | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | PPP1CB | 5,8,10,12,14 |
| C2_553 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | PPP1CC | 8 |
| C2_11251 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | PPP2CA | 11,13 |
| C2_7368 | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | PPP2CB | 11,13 |
| C2_7698 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | PPP2R1B | 11,13 |
| C2_22338 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | PPP3CA | 7 |
| C2_6942 | Calcineurin subunit B type 1 | PPP3R1 | 7 |
| C2_9126 | Protein kinase C beta type | PRKCB | 11 |
| C2_3156 | Ras-related protein Rab-11A | RAB11A | 7 |
| C2_452 | Ras-related protein Rab-11B | RAB11B | 7 |
| C2_9276 | Ras-related protein Rab-4B | RAB4B | 7 |
| C2_4291 | Ras-related protein Rab-5A | RAB5A | 7,16 |
| C2_6579 | Ras-related protein Rab-5B | RAB5B | 7,16 |
| C2_7828 | Ras-related protein Rab-5C | RAB5C | 7,16 |
| C2_53708 | Ras-related protein Rab7 | RAB7A | 7,16 |
| C2_1097 | Ras-related C3 botulinum toxin substrate 1 | RAC1 | 5,7,9,10,11,12,15,17 |
| C2_121610 | Ras-related C3 botulinum toxin substrate 2 | RAC2 | 5,10,12 |
| C2_935 | Ras-related protein Ral-B | RALB | 10 |
| C2_879 | Ras-related protein Rap-1b | RAP1B | 9,1 |
| C2_16564 | Radixin | RDX | 5,14,15,17 |
| C2_131 | Transforming protein RhoA | RHOA | 5,9,10,11,12,14,15,17 |
| C2_30428 | Rho-related GTP-binding protein RhoC | RHOC | 10,11,12,15,17 |
| C2_11478 | Rho-related GTP-binding protein RhoG | RHOG | 10,11,12,15,17 |
| C2_96072 | 60S ribosomal protein L10 | RPL10 | 8 |
| C2_67 | 60S ribosomal protein L10a | RPL10A | 8 |
| C2_236 | 60S ribosomal protein L11 | RPL11 | 8 |
| C2_587 | 60S ribosomal protein L12 | RPL12 | 8 |
| C2_453 | 60S ribosomal protein L13 | RPL13 | 8 |
| C2_441 | 60S ribosomal protein L13a | RPL13A | 8 |
| C2_142 | 60S ribosomal protein L14 | RPL14 | 8 |
| C2_279 | 60S ribosomal protein L15 | RPL15 | 8 |
| C2_1244 | 60S ribosomal protein L17 | RPL17 | 8 |
| C2_24040 | 60S ribosomal protein L18 | RPL18 | 8 |
| C2_12358 | 60S ribosomal protein L18a | RPL18A | 8 |
| C2_700 | 60S ribosomal protein L19 | RPL19 | 8 |
| C2_94336 | 60S ribosomal protein L21 | RPL21 | 8 |
| C2_39656 | 60S ribosomal protein L22 | RPL22 | 8 |
| C2_115552 | 60S ribosomal protein L22-like 1 | RPL22L1 | 8 |
| C2_373 | 60S ribosomal protein L23 | RPL23 | 8 |
| C2_1007 | 60S ribosomal protein L23a | RPL23A | 8 |
| C2_119969 | 60S ribosomal protein L24 | RPL24 | 8 |
| C2_392 | 60S ribosomal protein L26 | RPL26 | 8 |
| C2_102117 | 60S ribosomal protein L27 | RPL27 | 8 |
| C2_343 | 60S ribosomal protein L27a | RPL27A | 8 |
| C2_1383 | 60S ribosomal protein L28 | RPL28 | 8 |
| C2_12 | 60S ribosomal protein L3 | RPL3 | 8 |
| C2_17126 | 60S ribosomal protein L30 | RPL30 | 8 |
| C2_1127 | 60S ribosomal protein L31 | RPL31 | 8 |
| C2_72598 | 60S ribosomal protein L34 | RPL34 | 8 |
| C2_89835 | 60S ribosomal protein L35 | RPL35 | 8 |
| C2_11574 | 60S ribosomal protein L35a | RPL35A | 8 |
| C2_2019 | 60S ribosomal protein L36 | RPL36 | 8 |
| C2_1788 | 60S ribosomal protein L36a | Rpl36a | 8 |
| C2_796 | 60S ribosomal protein L37 | RPL37 | 8 |
| C2_64323 | 60S ribosomal protein L38 | RPL38 | 8 |
| C2_25 | 60S ribosomal protein L4 | RPL4 | 8 |
| C2_143 | 60S ribosomal protein L5 | RPL5 | 8 |
| C2_827 | 60S ribosomal protein L6 | RPL6 | 8 |
| C2_434 | 60S ribosomal protein L7 | RPL7 | 8 |
| C2_98 | 60S ribosomal protein L7a | RPL7A | 8 |
| C2_174 | 60S ribosomal protein L8 | RPL8 | 8 |
| C2_156 | 60S ribosomal protein L9 | RPL9 | 8 |
| C2_47 | 60S acidic ribosomal protein P0 | RPLP0 | 8 |
| C2_46323 | 60S acidic ribosomal protein P1 | RPLP1 | 8 |
| C2_6923 | 60S acidic ribosomal protein P2 | RPLP2 | 8 |
| C2_8805 | 40S ribosomal protein S10 | RPS10 | 8,11,13 |
| C2_367 | 40S ribosomal protein S11 | RPS11 | 8,11,13 |
| C2_583 | 40S ribosomal protein S12 | RPS12 | 8,11,13 |
| C2_20708 | 40S ribosomal protein S14 | RPS14 | 8,11,13 |
| C2_10570 | 40S ribosomal protein S15 | RPS15 | 8,11,13 |
| C2_414 | 40S ribosomal protein S15a | RPS15A | 8,11,13 |
| C2_7337 | 40S ribosomal protein S16 | RPS16 | 8,11,13 |
| C2_971 | 40S ribosomal protein S17 | RPS17 | 8,11,13 |
| C2_17339 | 40S ribosomal protein S18 | RPS18 | 8,11,13 |
| C2_955 | 40S ribosomal protein S19 | RPS19 | 8,11,13 |
| C2_62581 | 40S ribosomal protein S2 | RPS2 | 8,11,13 |
| C2_232 | 40S ribosomal protein S20 | RPS20 | 8,11,13 |
| C2_11917 | 40S ribosomal protein S21 | RPS21 | 8,11,13 |
| C2_1243 | 40S ribosomal protein S23 | RPS23 | 8,11,13 |
| C2_1271 | 40S ribosomal protein S24 | RPS24 | 8,11,13 |
| C2_310 | 40S ribosomal protein S25 | RPS25 | 8,11,13 |
| C2_698 | 40S ribosomal protein S26 | RPS26 | 8,11,13 |
| C2_33738 | Ubiquitin-40S ribosomal protein S27a | RPS27A | 8,11,13 |
| C2_50749 | 40S ribosomal protein S28 | RPS28 | 8,11,13 |
| C2_23479 | 40S ribosomal protein S29 | RPS29 | 8,11,13 |
| C2_17873 | 40S ribosomal protein S3 | RPS3 | 8,11,13 |
| C2_593 | 40S ribosomal protein S4 | RPS4 | 8,11,13 |
| C2_433 | 40S ribosomal protein S5 | RPS5 | 8,11,13 |
| C2_164 | 40S ribosomal protein S6 | RPS6 | 8,11,13 |
| C2_2840 | Ribosomal protein S6 kinase 2 alpha | RPS6KA1 | 11 |
| C2_38170 | Ribosomal protein S6 kinase alpha-3 | RPS6KA3 | 11 |
| C2_133 | 40S ribosomal protein S7 | RPS7 | 8,11,13 |
| C2_13671 | 40S ribosomal protein S8 | RPS8 | 8,11,13 |
| C2_252 | 40S ribosomal protein S9 | RPS9 | 8,11,13 |
| C2_16 | 40S ribosomal protein SA | RPSA | 8,11,13 |
| C2_23094 | Ras-related protein R-Ras | RRAS | 5,6,8,9,10,11,13 |
| C2_7026 | Ras-related protein R-Ras2 | RRAS2 | 5,6,8,9,10,11,13 |
| C2_16505 | Septin-10 | SEPT10 | 14,17 |
| C2_5603 | Septin-2 | SEPT2 | 14,17 |
| C2_22270 | Septin-6 | SEPT6 | 14,17 |
| C2_8875 | Septin-7 | SEPT7 | 14,17 |
| C2_9888 | Septin-8-A | SEPT8 | 14,17 |
| C2_14294 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | SERPINA1 | 6,7 |
| C2_9982 | Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | SERPINF2 | 6 |
| C2_9305 | Endophilin-A1 | SH3GL2 | 7 |
| C2_4801 | SHC-transforming protein 1 | SHC1 | 5,6,8,10,13 |
| C2_1642 | Superoxide dismutase [Mn], mitochondrial | SOD2 | 6 |
| C2_4186 | Protein phosphatase Slingshot homolog | SSH1 | 5 |
| C2_2871 | Signal transducer and activator of transcription 3 | STAT3 | 6 |
| C2_15171 | Transcription factor 7-like 2 | TCF7L2 | 9 |
| C2_7158 | Transferrin | TF | 6,7 |
| C2_83924 | Talin-1 | TLN1 | 5,1 |
| C2_1309 | Tumor necrosis factor receptor superfamily member 1B | TNFRSF1B | 6 |
| C2_45863 | Activated CDC42 kinase 1 | TNK2 | 10 |
| C2_2326 | Tumor necrosis factor receptor type 1-associated DEATH domain protein | TRADD | 6 |
| C2_1557 | Titin | TTN | 5,10,14 |
| C2_75383 | Transthyretin | TTR | 6 |
| C2_38179 | Tubulin alpha-1A chain | TUBA1A | 9,16 |
| C2_20113 | Tubulin alpha-4A chain | TUBA4A | 9,16 |
| C2_905 | Tubulin beta chain | TUBB | 9,16 |
| C2_90 | Tubulin beta-1 chain | TUBB1 | 9,16 |
| C2_14202 | Tubulin beta-2C chain | TUBB4B | 9,16 |
| C2_6783 | Ubiquitin-60S ribosomal protein L40 | UBA52 | 8 |
| C2_19855 | Probable ubiquitin carboxyl-terminal hydrolase FAF-X | USP9X | 7 |
| C2_9594 | Vinculin | VCL | 5,9,10,16 |
| C2_3381 | Vimentin | VIM | 17 |
Canonical pathways are indicated by number: (5) Actin cytoskeleton signaling; (6) Acute phase response signaling; (7) Clathrin-mediated endocytosis signaling; (8) EIF2 signaling; (9) Epithelial adherens junction signaling; (10) Integrin signaling; (11) mTOR signaling; (12) Regulation of actin based motility by Rho; (13) Regulation of eIF4 and p70S6K signaling; (14) RhoA signaling; (15) RhoGDI signaling; (16) Remodeling of epithelial adherens junctions; (17) Signaling by Rho family GTPase.