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. Author manuscript; available in PMC: 2017 Feb 2.
Published in final edited form as: Free Radic Biol Med. 2013 Dec 1;68:22–34. doi: 10.1016/j.freeradbiomed.2013.11.015

Fig. 2.

Fig. 2

Therapeutic effects of Zn on renal remodeling, inflammation, and oxidative damage in OVE26 type 1 diabetes mice. Renal structural changes were examined with (A) H&E and (B) Sirius red staining. Renal expression of TGF-β1 and CTGF, as indices of profibrotic mediators, was examined by (C) Western blot and (D) immunohistochemical staining. Renal expression of TNF-α, ICAM-1, and PAI-1, as indices of inflammation, and 4-HNE, as an index of lipid oxidation, was also detected by (E) Western blot assay and (F) immunohistochemical staining. Data are presented as the mean ± SD (n = 6). *p < 0.05 vs control (Ctrl); #p < 0.05 vs DM group. Bar, 50 μm.