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. Author manuscript; available in PMC: 2017 Feb 2.
Published in final edited form as: Free Radic Biol Med. 2013 Dec 1;68:22–34. doi: 10.1016/j.freeradbiomed.2013.11.015

Fig. 4.

Fig. 4

Therapeutic effects of Zn on renal functional and pathological changes in Akt2-KO diabetic mice. Two-month-old male Akt2-KO mice and FVB control mice were given Zn (5 mg/kg) or physiological saline every other day for 3 months. (A) Urinary ACR and (B) kidney weight (KW) to body weight (BW) ratio were measured. Renal pathology was examined with (C) H&E and (D) Sirius red staining. Renal expression of TGF-β1 and CTGF was tested by (E) Western blot assay and (F) immunohistochemical staining. Data are presented as the mean ± SD (n = 6). *p < 0.05 vs control (Ctrl); #p < 0.05 vs Akt2-KO. Bar, 50 μm.