Table 2.
Results of cohort studies included in the systematic review for the asbestos-smoking interaction
| Author (Year) | Subjects | Cases (sub-cohort) | Follow-up | NS/Exposed | S/Exposed | Interaction Estimation | Interpretation | ||
|---|---|---|---|---|---|---|---|---|---|
| Additive | Multiplicative | Additive | Multiplicative | ||||||
| Berry (1985) [24] | M: 1250 F: 420 |
M: 64 F: 15 |
1971–1980 | RR = 7.3 | RR = 2.4 | NA | RAE = 3.0 (0.8-7.5) | NA | No |
| Liddell (2002) [26] | M: 7279 | M: 533 | 1904–1992 | SMR = 0.62 | SMR = 1.71 | S = 1.1 (0.73-1.41) | RAE = 1.69 (0.87-3.28) | No | No |
| Reid (2006) [23] | M: 2550 F: 183 |
M: 132 F: 6 |
1979–2002 | OR = 2.02 (0.61–6.72) | OR = 1.64 (1.124–2.37) | NA | RAEm = 1.59 (0.12-20.50) | NA | No |
| Frost (2011) [25] | M: 93966 | M: 1768 | 1971–2005 | RR = 1.6 (0.6–4.2) | RR = 26.2 (13.0–53.1) | S = 1.4 (1.2-1.6) | V = 0.9 (0.3-2.4) | Positive | No |
| Wang (2012) [22] | M: 1539 | M: 50 | 1981–2006 | SMR = 1.79 (0.49-6.51) | SMR = 5.45 (4.11-7.22) | NA | RAE = 0.52 (0.07-1.11) | NA | No |
| Wang (2012) [28] | M: 577 | M: 53 | 1972–2008 | HR = 7.52 (0.90-62.79) | HR = 17.35 (2.38-126.57) | S = 1.41 (0.73-3.99) | NA | No | NA |
| Offermans (2014) [27] | M: 2324 | M: 2107 | 1986–2003 | HR = 1.79 (1.04–3.08) | HR = 10.21 (7.26–14.35) | RERI = 1.94 (0.13-4.89) | IT P = 0.50 | No | No |
M Males, F Females, S smokers, NS non-smokers, S Synergy Index, RERI Relative Excess Risk due to Interaction, V Multiplicativity Index, RAE Relative Asbestos Effect, RAE m the Modified Relative Asbestos Effect