Table 4.
Results of case–control studies included in the systematic review for the asbestos-smoking interaction
| Author (Year) | Cases | Controls | Recruitment period | NS /Exposed | S/Exposed | Interaction Estimation | Interpretation | ||
|---|---|---|---|---|---|---|---|---|---|
| Additive | Multiplicative | Additive | Multiplicative | ||||||
| Martischnig (1977) [29] | M: 201 | M: 201 | 1972–1973 | RR = 1.08 | ≥25 C/D: RR = 3.26 |
NA | No heterogeneity of RRs X2 = 2.89; DF =2 | NA | No |
| Blot (1978) [30] | M: 458 | M: 553 | 1970–1976 | RR = 1.3 | RR = 1.7 RR = 2.4 |
NA | No heterogeneity of RRs P > 0.10 | NA | No |
| Jöckel (1998) [31] | M: 839 F: 165 |
M: 839 F: 165 |
1988-1993 | OR = 1.1 | OR = 6.5 OR = 18 |
NA | IT P = 0.73 |
NA | No |
| Gustavsson (2002) [35] | M: 1038 | M: 2359 | 1985–1990 | RR = 4.2 (1.6-11.1) | RR = 28.6 (19.9-48.3) | S = 1.15 (0.77-1.72) | IT OR = 0.31 (0.11-0.86) |
No | Negative |
| Carel (2007) [32] | M: 2205 | M: 2305 | 1998–2002 | Not shown | Not shown | NA | No modification effect CEE: P = 0.37 UK P = 0.62. | NA | No |
| De Matteis (2012) [6] | M: 1537 | M: 1617 | 2002–2005 | OR = 2.47 (1.15-5.31) | OR = 49.54 (28.18-87.08) | NA | LRT P = 0.19 |
NA | No |
| Villeneuve (2012) [33] | M: 1681 | M: 2053 | 1994–1997 | OR = 2.20 (0.42-11.41) | OR = 38.59 (10.78-138.08) | NA | IT P = 0.77 |
NA | No |
| Lacourt (2015) [34] | M: 414 | M: 321 | St.1: 1979–1986 St.2: 1996–1998 | OR = 1.2 (0.7–2.2) | OR = 1.1 (0.8–1.6) | NA | IT P = 0.68 |
NA | No |
M Males, F Females, S Smokers, NS Non-Smokers, CEE Central and Eastern Europe, St Study, S Synergy Index, LRT likelihood ratio test, IT interaction term