Table 6.
Results of silica-smoking and diesel-smoking interaction studies included in the systematic review
| Author (Year) | Subjects (cases) | Cases (controls) | Perioda | NS/Exposed | S/Exposed | Interaction Estimation | Interpretation | ||
|---|---|---|---|---|---|---|---|---|---|
| Additive | Multiplicative | Additive | Multiplicative | ||||||
| Silica-smoking interaction studies | |||||||||
| Liu (2013) [36] | 34018 | 546 | 1960–2003 | HR = 1.10 (0.68-1.78) | HR = 3.83 (2.48-5.90) | RERI = 0.98 (0.23-1.74) |
IT P = 0.25 |
No | No |
| Fu (1994) [37] | M: 79 | M: 188 | 1973–1989 | NA | NA | NA | IT P = 0.57 |
NA | No |
| Cassidy (2007) [38] | M: 2197 F: 655 |
M: 2295 F: 809 |
1998–2002 | OR = 1.41 (0.79 -2.49) | OR = 1.41 (1.07-1.87) | NA | Test for Heterogeneity P = 0.37 | NA | No |
| De Matteis (2012) [6] | M: 1537 | M: 1617 | 2002–2005 | OR = 1.41 (0.51-3.91) | OR = 44.98 (27.15-74.52) | NA | LRT P = 0.94 |
NA | No |
| Kachuri (2014) [39] | M: 1681 | M: 2053 | 1994–1997 | OR = 0.63 (0.26-1.52) | OR = 42.53 (23.54-76.83) | S = 2.38 (1.35-4.21) |
V = 3.59 (1.51-8.49) |
Positive | Positive |
| Consonni (2015) [40] | M: 15608 | M: 18531 | 1985–2010 | OR = 1.18 | OR = 18.5 | RERI = 6.80 (4.36-9.62) |
IT P = 0.28 |
Positive | No |
| Lacourt (2015) [34] | M: 241 | M: 196 | St.1: 1979–1986 St.2: 1996–1998 | OR = 3.1 (1.0–9.6) | OR = 1.4 (0.7–2.7) | NA | IT P = 0.02 |
NA | Negative |
| Diesel-smoking interaction studies | |||||||||
| Silverman (2012) [41] | M: 198 | M: 562 Ma | 1947–1977 | OR = 7.30 (1.46- 36.57) | OR = 17.38 (3.48-86.73) | NA | IT P = 0.086 |
NA | No |
| Pintos (2012) [42] | St. I: M: 857 St. II: M: 736 | St. I: M: 533 St. II: M: 894 | St. I: 1979–1986 St. II: 1996–2001 |
OR = 2.29 (1.1-4.6) | OR = 9.84 (6.4-15.1) | NA | IT OR = 1.15 (0.5-2.7) |
NA | No |
M Males, F Females, S Smokers, NS Non-Smokers, NA Not Applicable, S Synergy Index, V Multiplicativity Index, RERI Relative Excess Risk due to Interaction, LRT likelihood ratio test, IT interaction term
a: Follow-up or recruitment period