Table 2.

Aging-associated pathologies in Ink4a/Arf (+/+) and (+/+;tg/·) mice

Genotype	Mousea (#, sex)	Lifespan (months)	Main pathological findings	Presence of neoplasias
(+/+)	1, F	31	multicentric lymphoma	yes
	2, M	26	without significant findings	no
	3, M	25	multicentric lymphoma	yes
	4, M	24	without significant findings	no
	5, M	24	liver carcinoma & liver metastasis	yes
	6, M	21	hemangiosarcoma and lymphoma	yes
	7, F	21	ulcerative cutaneous papilloma	yes
	8, F	17	without significant findings	no
	9, F	17	without significant findings	no
	10, M	13	ulcerative tricoepithelioma	yes
			TOTAL MICE WITH NEOPLASIAS	6/10 (60%)
(+/+;tg/·)	1, F	34	without significant findings	no
	2, F	34	without significant findings	no
	3, F	25	cutaneous papilloma	yes
	4, F	25	without significant findings	no
	5, M	24	lung congestion	no
	6, M	23	without significant findings	no
	7, F	22	splenic lymphoma, pneumonia	yes
	8, M	13	without significant findings	no
	9, F	12	without significant findings	no
			TOTAL MICE WITH NEOPLASIAS	2/9 (22%)

^aThe table includes animals that died spontaneously at an advanced age; some of them were not part of the cohorts analyzed in Figure 6B