Table 2.
Cox proportional hazards survival models including mdNLR, age, grade, and tumor mutation status
| n deceased | Survival years | Univariate models | Multivariate model | |||||
|---|---|---|---|---|---|---|---|---|
| Number | Mean | Median | HR (95% CI) | p value | HR (95% CI) | p value | ||
| mdNLR < 4 mdNLR > = 4 |
44 28 |
35 23 |
4.8 3.1 |
4.3 1.8 |
Referent group 1.78 (1.03–3.07) |
0.038 | Referent group 2.02 (1.11–3.69) |
0.022 |
| GBM non-GBM |
33 39 |
32 26 |
2.9 5.3 |
1.7 5.3 |
Referent group 0.48 (0.28–0.81) |
0.006 | Referent group 1.06 (0.56–2.00) |
0.859 |
|
IDH only TERT only |
30 42 |
18 40 |
6.6 2.4 |
7.2 1.4 |
4.19 (2.34–7.48) | <0.0001 | referent group 4.83 (2.35–9.93) |
0.00002 |
| Age (continuous) | 0.97 (0.92–1.02) | 0.274 | ||||||
All covariates modeled met proportionality assumptions
HR hazard ratio, CI confidence interval
MdNLR methylation-derived NLR (neutrophil to lymphocyte ratio)