Table 5.
Cox proportional hazards survival models including, age, sex, grade, mutation status, and either mdNLR or cg00901982 (linear and quadratic terms)
| Baseline model | Baseline + mdNLR | Baseline + CpG | Baseline + CpG + CpG2 | |||
|---|---|---|---|---|---|---|
| n (%) | Median (IQR) | HR (95%CI) | HR (95%CI) | HR (95%CI) | HR (95%CI) | |
| Age | 47 (44, 54) | 0.99 (0.94, 1.05) | 0.97 (0.92, 1.03) | 0.99 (0.94, 1.04) | 0.97 (0.92, 1.03) | |
| Female | 20 (28) | Referent group | Referent group | Referent group | Referent group | |
| Male | 52 (72) | 0.75 (0.41, 1.38) | 0.74 (0.40, 1.35) | 0.74 (0.40, 1.35) | 0.69 (0.37, 1.26) | |
| mdNLR >4 | 28 (39) | Referent group | ||||
| mdNLR ≤4 | 44 (61) | 0.49 (0.27, 0.90) | ||||
| IDH only | 30 (42) | Referent group | Referent group | Referent group | Referent group | |
| TERT only | 42 (58) | 3.96 (1.98, 7.94) | 4.56 (2.20, 9.43) | 4.25 (2.09, 8.64) | 4.65 (2.25, 9.62) | |
| GBM | 33 (46) | Referent group | Referent group | Referent group | Referent group | |
| Non-GBM | 39 (54) | 0.92 (0.50, 1.71) | 1.02 (0.54, 1.92) | 0.98 (0.52, 1.82) | 0.90 (0.48, 1.70) | |
| cg00901982* | 26.1 (21.4, 31.2) | 0.80 (0.52, 1.22) | 0.36 (0.04, 3.15) | |||
| cg009019822* | 29 (3.52, 237) | |||||
| Concordance | 0.71 (SE = 0.04) | 0.73 (SE = 0.04) | 0.72 (SE = 0.04) | 0.74 (SE = 0.04) | ||
| Brier score | 0.1508 | 0.1506 | 0.1511 | 0.1468 | ||
| Lrtest vs baseline model | 0.02 | 0.29 | 0.01 | |||
| Lrtest vs baseline + mdNLR model | <0.0001 | 0.06 | ||||
| Lrtest model linear (CpG) vs quadratic (CpG + CpG2) model | 0.01 | |||||
p values <0.05 are highlighted in bold font
All covariates modeled met proportionality assumptions
HR hazard ratio, CI confidence interval, mdNLR methylation-derived neutrophil lymphocyte ratio, Lrtest likelihood ratio test
*Per every 10% increase in methylation