Table 6.
Cox proportional hazards survival models including, age, sex, grade, mutation status, mdNLR and cg00901982 (linear and quadratic terms)
| Baseline model | Baseline + NLR | Baseline + mdNLR + CpG | Baseline + mdNLR + CpG + CpG2 | |||
|---|---|---|---|---|---|---|
| n (%) | Mean (sd) | HR (95%CI) | HR (95%CI) | HR (95%CI) | HR (95%CI) | |
| Age | 47 (44, 54) | 0.99 (0.94, 1.05) | 0.97 (0.92, 1.03) | 0.97 (0.92, 1.03) | 0.97 (0.92, 1.02) | |
| Female | 20 (27.8) | Referent group | Referent group | Referent group | Referent group | |
| Male | 52 (72.2) | 0.75 (0.41, 1.38) | 0.74 (0.4, 1.35) | 0.74 (0.41, 1.36) | 0.7 (0.38, 1.29) | |
| mdNLR ≥4 | 28 (38.9) | Referent group | Referent group | Referent group | ||
| mdNLR <4 | 44 (61.1) | 0.49 (0.27, 0.9) | 0.40 (0.17, 0.92) | 0.69 (0.26, 1.81) | ||
| IDH only | 30 (41.7) | Referent group | Referent group | Referent group | Referent group | |
| TERT only | 42 (58.3) | 3.96 (1.98, 7.94) | 4.56 (2.20, 9.43) | 4.49 (2.16, 9.35) | 4.73 (2.26, 9.88) | |
| GBM | 33 (45.8) | Referent group | Referent group | Referent group | Referent group | |
| Non-GBM | 39 (54.2) | 0.92 (0.50, 1.71) | 1.02 (0.54, 1.92) | 1.00 (0.53, 1.90) | 0.92 (0.48, 1.76) | |
| cg00901982* | 26.1 (21.4, 31.2) | 1.20 (0.72, 1.99) | 0.91 (0.03, 24.7) | |||
| cg009019822* | 15.9 (1.12, 225) | |||||
| Concordance | 0.71(SE = 0.04) | 0.73(SE = 0.04) | 0.74(SE = 0.04) | 0.74(SE = 0.04) | ||
| Brier score | 0.1508 | 0.1506 | 0.1504 | 0.1473 | ||
| Lrtest vs baseline model | 0.02 | 0.06 | 0.02 | |||
| Lrtest vs baseline + mdNLR model | 0.49 | 0.13 | ||||
| Lrtest model linear (CpG) vs quadratic (CpG + CpG2) model | 0.06 | |||||
p values <0.05 are highlighted in bold font
All covariates modeled met proportionality assumptions
HR hazard ratio, CI confidence interval, mdNLR methylation-derived neutrophil lymphocyte ratio, Lrtest likelihood ratio test
*Per every 10% increase in methylation