Table 1. . DNA methylation profiles in chondrosarcoma.

Gene	Sample	Function	Methylation status	Ref.
MDK	Rat CS cells	Growth factor	Induced hypomethylation†	[18]
Sox2	Rat CS cells	Pluripotent transcription factor	Induced hypomethylation†	[18]
Satellite 1	Rat CS cells, rat CS tissues	Repetitive DNA elements	Global hypomethylation	[18,20]
LINE-1	Rat CS cells	Repetitive DNA elements	Global hypomethylation	[18]
Maspin	Human CS cell lines	Epithelial-specific marker	Hypomethylation	[39]
14-3-3σ	Human CS cell lines	Epithelial-specific marker	Hypomethylation	[39]
p16INK4a (CDKN2A)	Human CS tissues	Inhibitor of cyclin-dependent kinase	Hypermethylation	[26,27]
FHIT	Human CS tissues	Induce apoptosis and in cell-cycle control	Hypermethylation	[27]
E-cadherin (CDH1)	Human CS tissues	Cell adhesion	Hypermethylation	[27]
3-OST	Human CS cell lines	HS biosynthetic enzymes	Hypermethylation	[28]
RUNX3	Human CS tissues	Induce cell cycle arrest and apoptosis	Hypermethylation	[25]

^†Induced hypomethylation denotes certain gene is detected as hypomethylated after using DNA methyltransferase inhibitor but unknown methylation status in CS.

CS: Chondrosarcoma; HS: Heparan sulfate.