Table 1.
Main characteristics of all eligible studies
| First author | Year | Country | Ethnicity | Eligible participants (M/F) | Age, mean (SD), years | Genotype method | SNPa | HWE | NOS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | ||||||||
| Salih et al. | 2016 | Turkey | Caucasian | 288 (137/151) | 288 (133/155) | 31.26 (10.28) | 31.53 (8.92) | RT-PCR | 1,2 | yes | 6 |
| Heidi et al. | 2014 | Australia | Caucasian | 277 | 277 | - | - | PCR-RFLP | 1,2 | yes | 7 |
| Heidi et al. | 2014 | Australian | Caucasian | 580 | 580 | - | - | PCR-RFLP | 1,2 | yes | 7 |
| Carolina et al. | 2010 | Portugal | Caucasian | 188 (35/153) | 287 (70/217) | 36.14 (12.84) | 36.42 (12.35) | RT-PCR | 1,2 | yes | 7 |
| Martin et al. | 2008 | German | Caucasian | 265 (43/222) | 153 (43/110) | 43.6 (13) | 64.5 (9.4) | RT-PCR | 1 | yes | 7 |
Abbreviation: M male, F female, SNP single-nucleotide polymorphism, HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa scale, PCR-RELP polymerase chain reaction-restricted fragments length polymorphism, RT-PCR real-time polymerase chain reaction
a1 = rs6265; 2 = rs2049046