Table 2.
Distribution of genotype and allele of BDNF polymorphism between cases and controls
| rs number | Source | Group | N | Genotypes (N,freq) | Alleles (N,freq) | |||
|---|---|---|---|---|---|---|---|---|
| rs6265(G/A) | GG | GA | AA | G | A | |||
| Salih et al. | cases | 288 | 196 (68.1%) | 84 (29.2%) | 8 (2.8%) | 476 (82.6%) | 100 (17.4%) | |
| controls | 288 | 217 (75.3%) | 66 (22.9%) | 5 (1.7%) | 500 (86.8%) | 76 (13.2%) | ||
| Heidi et al. | cases | 201 | 131 (65.2%) | 64 (31.8%) | 6 (3.0%) | 326 (81.1%) | 76 (18.9%) | |
| controls | 246 | 171 (69.5%) | 68 (27.6%) | 7 (2.8%) | 410 (83.3%) | 82 (16.7%) | ||
| Heidi et al. | cases | 411 | 265 (64.5%) | 129 (31.4%) | 17 (4.1%) | 659 (80.2%) | 163 (19.8%) | |
| controls | 546 | 373 (68.3%) | 156 (28.6%) | 17 (3.1%) | 902 (82.6%) | 190 (17.4%) | ||
| Carolina et al. | cases | 188 | 118 (62.8%) | 64 (34.0%) | 6 (3.2%) | 300 (79.8%) | 76 (20.2%) | |
| controls | 287 | 183 (63.8%) | 95 (33.1%) | 9 (3.1%) | 461 (80.3%) | 113 (19.7%) | ||
| Martin et al. | cases | 265 | 148 (55.9%) | 104 (39.2%) | 13 (4.9%) | 400 (75.5%) | 130 (24.5%) | |
| controls | 153 | 88 (57.5%) | 57 (37.3%) | 8 (5.2%) | 233 (76.1%) | 73 (23.9%) | ||
| Meta-analysis | cases | 1353 | 858 (63.4%) | 445 (32.9%) | 50 (3.7%) | 2161 (79.9%) | 545 (20.1%) | |
| controls | 1520 | 1032 (67.9%) | 442 (29.1%) | 46 (4.5%) | 2506 (82.4%) | 534 (17.6%) | ||
| rs2049046(A/T) | AA | AT | TT | A | T | |||
| Salih et al. | cases | 288 | 64 (22.2%) | 147 (51.0%) | 77 (26.7%) | 275 (47.7%) | 301 (52.3%) | |
| controls | 288 | 82 (28.5%) | 128 (44.4%) | 78 (27.1%) | 292 (50.7%) | 284 (49.3%) | ||
| Heidi et al. | cases | 235 | 46 (19.6%) | 115 (48.9%) | 74 (31.5%) | 207 (44.0%) | 263 (56.0%) | |
| controls | 244 | 60 (24.6%) | 128 (52.5%) | 56 (23.0%) | 248 (50.8%) | 240 (49.2%) | ||
| Heidi et al. | cases | 549 | 111 (20.2%) | 279 (50.8%) | 159 (29.0%) | 501 (45.6%) | 597 (54.4%) | |
| controls | 561 | 135 (24.1%) | 280 (49.9%) | 146 (26.0%) | 550 (49.0%) | 572 (51.0%) | ||
| Carolina et al. | cases | 188 | 51 (27.1%) | 99 (52.7%) | 38 (20.2%) | 201 (53.5%) | 175 (46.5%) | |
| controls | 287 | 79 (27.5%) | 143 (49.8%) | 65 (22.6%) | 301 (52.4%) | 273 (47.6%) | ||
| Meta-analysis | cases | 1260 | 272 (21.6%) | 640 (50.8%) | 348 (27.6%) | 1184 (47.0%) | 1336 (53.0%) | |
| controls | 1380 | 356 (25.8%) | 679 (49.2%) | 345 (25.0%) | 1391 (50.4%) | 1369 (49.6%) | ||
Abbreviation: BDNF brain-derived neurotrophic factor