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. Author manuscript; available in PMC: 2017 Feb 2.
Published in final edited form as: Neurobiol Aging. 2014 Jul 15;36(1):505–518. doi: 10.1016/j.neurobiolaging.2014.07.011

Figure 10.

Figure 10

Rats expressing G2019S LRRK2 (TG) exhibit evidence of increased expression inducible nitric oxide synthase (iNOS) in nigral dopamine (DA) neurons. Fluorescence immunostaining was performedin coronal brain sections for TH-immunopositive neurons (A, E) and iNOS (B, F). Regions of interest (ROIs) were drawn around DAergic neurons (TH+) in the pars compacta region of the SN. Quantitative immunofluorescence is reported (I, J) relative to mean control values (WT). ***p <0.001 vs. WT; n = 5/group; Student’s t-test (data expressed as mean ± S.E.M.). TH fluorescence intensity was similar between the experimental groups. Magnification bar = 20 µm.