Table 3.

Nonsynonymous Substitution Support

	≥3 Human mRNA/EST	≥3 Non-human mRNA/EST	No support
Genome only	7144 (64.7%)	5823 (52.7%)	659 (6.0%)
mRNA only	754 (6.8%)	677 (6.1%)	5737 (52.0%)
Genome and mRNA	1183 (10.7%)	396 (3.6%)	372 (3.4%)
Neither	1960 (17.8%)	4145 (37.5%)	N/A

Analysis of 11,041 nonsynonymous substitutions in alignments of CDS regions of full-length mRNAs to the human genome sequence. Sequences are compared against other human and nonhuman mRNA and EST sequences that align at this position. Reported are the number of instances in which three or more other human (column 2) or nonhuman (column 3) mRNA or EST sequences agree with each. The last column indicates how many have no other human or nonhuman mRNA or EST support at all. The first row shows the number of times only the genome has the corresponding level of support; the second row, the same for the mRNA. The third row shows how many times both the genome and the mRNA are supported at the level indicated; the last row, when neither have that level of support.