Table 2.

Multivariate Cox proportional hazard analysis for local recurrence-free survival

Variable	Multivariate analysis
	HR	95% CI	p value
Tumor location
Extremity	1	0.7–4.4	0.19
Central	1.8
Vascular invasion
No	1	0.9–3.9	0.07
Yes	1.9
MSTS surgical margins
Radical	1	0.7–39 0.8–45 1.2–82	0.11 0.07 0.03
Wide	5.2
Marginal	6.2
Intralesional	9
Chemotherapy necrosis
≥ 90%	1	1.7–8.4	0.001
< 90%	3.8

HR = hazard ratio; CI = confidence interval; MSTS = Musculoskeletal Tumor Society.