Table II.
Demographic and clinicopathological factors and leptin and adiponectin levels in association with hepatocellular carcinoma liver transplantation and survival.
| Variables | Liver transplantation, No (%)
|
p-Value | Survival status, No (%)
|
p-Value | ||
|---|---|---|---|---|---|---|
| No | Yes | Alive | Dead | |||
| Age group | ||||||
| <62.6 years | 63 (73.3) | 23 (26.7) | 42 (48.8) | 44 (51.2) | ||
| ≥62.6 years | 72 (83.7) | 14 (16.3) | 0.095 | 36 (41.9) | 50 (58.1) | 0.358 |
| Gender | ||||||
| Female | 30 (81.1) | 7 (18.9) | 16 (43.2) | 21 (56.8) | ||
| Male | 105 (77.8) | 30 (22.2) | 0.665 | 62 (45.9) | 73 (54.1) | 0.772 |
| Race/ethnicity | ||||||
| Non-Hispanic White | 63 (76.8) | 19 (23.2) | 35 (42.7) | 47 (57.3) | ||
| Others | 72 (80.0) | 18 (20.0) | 0.613 | 43 (47.8) | 47 (52.2) | 0.503 |
| Hepatitis B virus infection | ||||||
| Negative | 111 (77.6) | 32 (22.4) | 62 (43.4) | 81 (56.6) | ||
| Positive | 24 (82.8) | 5 (17.2) | 0.539 | 16 (55.2) | 13 (44.8) | 0.244 |
| Hepatitis C virus infection | ||||||
| Negative | 59 (81.9) | 13 (18.6) | 30 (41.7) | 42 (58.3) | ||
| Positive | 76 (76.0) | 24 (24.0) | 0.349 | 48 (48.0) | 52 (52.0) | 0.411 |
| Alcohol drinking history | ||||||
| No | 100 (80.7) | 24 (19.3) | 52 (41.9) | 72 (58.1) | ||
| Yes | 35 (72.9) | 13 (27.1) | 0.269 | 26 (54.2) | 22 (45.8) | 0.148 |
| Cigarette smoking | ||||||
| Never | 52 (81.3) | 12 (18.7) | 28 (43.8) | 36 (56.2) | ||
| Ever | 77 (77.0) | 23 (23.0) | 0.517 | 46 (46.0) | 54 (54.0) | 0.778 |
| Diabetes mellitus history | ||||||
| No | 72 (74.2) | 25 (25.8) | 47 (48.5) | 50 (51.5) | ||
| Yes | 63 (84.0) | 12 (16.0) | 0.122 | 31 (41.3) | 44 (58.7) | 0.352 |
| Body mass index at enrollment (kg/m2) | ||||||
| <30 | 44 (84.6) | 8 (15.4) | 25 (48.1) | 27 (51.9) | ||
| ≥30.0 | 78 (74.3) | 27 (25.7) | 0.143 | 46 (43.8) | 59 (56.2) | 0.613 |
| Waist to hip ratio | ||||||
| <0.953 | 60 (78.9) | 16 (21.1) | 37 (48.7) | 39 (51.3) | ||
| ≥0.953 | 59 (76.6) | 18 (23.4) | 0.729 | 32 (41.6) | 45 (58.4) | 0.376 |
| α-fetoprotein (ng/ml) | ||||||
| <48 | 58 (68.2) | 27 (31.8) | 49 (57.7) | 36 (42.4) | ||
| ≥48 | 77 (88.5) | 10 (11.5) | 0.001 | 29 (33.3) | 58 (66.7) | 0.001 |
| Child-Pugh class | ||||||
| A | 82 (77.4) | 24 (22.6) | 52 (49.1) | 54 (50.9) | ||
| B | 52 (80.0) | 13 (20.0) | 0.684 | 25 (38.5) | 40 (61.5) | 0.176 |
| Metastasis | ||||||
| No | 107 (74.8) | 36 (25.2) | 73 (51.1) | 70 (48.9) | ||
| Yes | 19 (100.0) | 0 (0.0) | 0.013 | 2 (10.5) | 17 (89.5) | 0.001 |
| Milan criteria | ||||||
| Within | 39 (60.0) | 26 (40.0) | 44 (67.7) | 21 (32.3) | ||
| Outside | 96 (89.7) | 11 (10.3) | <0.0001 | 34 (31.8) | 73 (68.2) | <0.0001 |
| Barcelona clinic liver cancer stage | ||||||
| 0, A | 40 (64.5) | 22 (35.5) | 41 (66.1) | 21 (33.9) | ||
| B, C | 95 (86.4) | 15 (13.6) | 0.001 | 37 (33.6) | 73 (66.4) | <0.0001 |
| Leptin (ng/ml) | ||||||
| <Median | 70 (84.3) | 13 (15.7) | 37 (44.6) | 46 (55.4) | ||
| ≥Median | 65 (73.0) | 24 (27.0) | 0.071 | 41 (46.1) | 48 (53.9) | 0.845 |
| Adiponectin (μg/ml) | ||||||
| <Median | 68 (79.1) | 18 (20.9) | 42 (48.8) | 44 (51.2) | ||
| ≥Median | 67 (77.9) | 19 (22.1) | 0.853 | 36 (41.9) | 50 (58.1) | 0.358 |