Figure EV1. Drugs with similar targets and chemogenomic profiles can have both synergistic and antagonistic interactions.

Combinations highlighted in this plot tobramycin–spectinomycin, tobramycin–gentamicin, and fusidic acid–clarithromycin share similar chemogenomic profiles, as measured by the correlation between their chemogenomic profiles, and similar target processes. Yet they have antagonistic, neutral, or synergistic outcomes, suggesting that chemogenomic profile or target similarity is not a strong predictor of drug‐interaction outcome.