Table 2.
Liposome Formulation | R (5FURW:DOX) | DOX Incorporation (mol%) | 5FURW Incorporation (mol%) | Size (nm) | Zeta Potential (mV) |
---|---|---|---|---|---|
ant DAFODIL | 12.2 | 0.45 ± 0.02 | 5.47 ± 0.94 | 156.9 ± 5.7 | 36.2 ± 0.5 |
-PEG DAFODIL | 0.18 | 7.75 ± 0.09 | 1.41 ± 0.47 | 149.8 ± 15.1 | 35.7 ± 4.3 |
DAFODIL | 0.15 | 14.82 ± 0.69 | 2.17 ± 0.23 | 168.8 ± 18.7 | −23.0 ± 3.0 |
Lipid composition was 80:10:10 DSPC:DOTAP:Chol, except for DAFODIL, which consisted of 75:5:10:10 DSPC:mPEG-DSPE:DOTAP:Chol. Drug loadings and DLS measurements are reported as mean ± SD (N≥3).