. Author manuscript; available in PMC: 2017 Sep 28.

Published in final edited form as: J Control Release. 2016 Jul 30;238:176–185. doi: 10.1016/j.jconrel.2016.07.051

Table 3.

Apparent permeability coefficient for transport of different sized particles across intestinal cell culture.

	Apparent Permeability coefficient (× 10⁻⁷ cm/sec)

	Caco-2	Caco-2/Raji-B	Caco-2/HT-29	Caco-2/HT-29/RajiB
50 nm	2.8 ± 0.3	202.6 ± 42.01	4.1 ± 1.3	210.9 ± 8.6
200 nm	1.1 ± 0.4	167.4 ± 9	2.4 ± 1.3	188 ± 19.3
500 nm	0.2 ± 0.2	127.6 ± 6.3	2 ± 1.9	142 ± 9.7^#^*
1000 nm	0.5 ± 0.04	60.5 ± 10.5	0.7 ± 0.2	75.4 ± 12.2^#^*⁺

represents statistically significant difference between 50 nm spheres and 500/1000 nm spheres in the triple co-culture; No significant difference in the Papp values was found between 50 and 200 nm spheres.

represents statistically significant difference between 200 nm sized particles and 500/1000 nm sized particles.

⁺

represents significant difference between 500 nm spheres and 1000 nm spheres (p < 0.05). All statistical analysis was performed for Papp values obtained from triple co-culture only.