Table 1.

Summary of HLA-A mismatches between lung allograft donors and recipients, and clinical features following human lung transplantation.

I.D.	Diseasea	LTxb	HLA-A allele: Donor		HLA-A allele:Recipient		DSA-Ac	Auto Abd	BOSe	ARf
P1	CF	1	A2	A33	A3	A68	+	+++	2	2
P2	IPF	1	A3	A33	A2	A24	+	++	3	2
P3	IPF & RA	1	A3	A3	A2	A24	+/−	+	0-p	1
P4	COPD	1	A2	A26	A3	A11	+/−	+/−	Neg	2
P5	A1AD	1	A2	A2	A25	A32	+	++	1	1
P6	IPF	1	A2	A3	A24	A25	+/−	++	1	2
P7	IPF	1	A2	A30	A66	A69	+/−	+	Neg	1
P8	COPD	1	A3	A68	A43	A68	+/−	++	Neg	2
P9	CF	1	A2	A29	A11	A30	+	+/−	0-p	1
P10	CTD	1	A2	A34	A69	A80	+	+++	2	2
P11	CF	1	A11	A33	A3	A24	+	++	Neg	2
P12	COPD	1	A11	A33	A2	A3	+	++	0	1
P13	IPF	1	A30	A32	A3	A68	+	+++	1	3
P14	CF	1	A24	A66	A2	A31	+/−	+	0-p	2
P15	PAH	1	A69	A80	A3	A26	+	+/−	Neg	2

^aCF, cystic fibrosis; IPF, idiopathic pulmonary fibrosis; RA, rheumatoid arthritis; COPD, chronic obstructive pulmonary disease; A1AD, alpha 1 anti-trypsin deficiency; CTD, connective tissue disease; PAH, pulmonary arterial hypertension

^b1, primary transplantation (bilateral); 2, re-transplantation (bilateral)

^cDSA determination performed by LABScreen Single Antigen assay (One Lambda Inc): +, persistent/ recurrent DSA; +/−, resolved DSA; −, DSA negative

^dAb to Collagen V or Kα1Tubulin measured by ELISA: +++, strong positive; ++, moderate positive; +, weak positive; −, negative

^eBronchiolitis Obliterans Syndrome (BOS) grade at clinical diagnosis; Neg, negative for BOS

^fGrade of acute rejection (AR)