Fig 1. PBPK-based in vivo contextualization of in vitro toxicity data (PICD).
INPUT: At the organism level, PBPK models are developed for specific drugs. At the cellular level, in vitro response data of compound-treated primary hepatocytes are analyzed (28). COUPLING: In vivo doses are identified, which are directly related to in vitro drug exposure (AUCin vivo = AUCin vitro). Time-dependent dose-response curves are built by mapping in vivo doses to in vitro responses. CONTEXTUALIZATION: By use of the time-dependent dose-response curves drug responses over time are predicted for PK profiles simulated for different doses. (Illustration of cells and parts of human body adapted with permission [75], https://creativecommons.org/licenses/by/4.0/)