Fig 4. a-d. Trans-eQTL findings for SNPs in BRCA2, EMID1, FTO, and ZMIZ1.

In Fig 4a, the coding SNP in BRCA2 exhibits statistically significant association with expression of TRPC6, but the result is based on a single individual with a single copy of the rare allele. In Fig 4b, an intronic SNP in FTO shows association specific to ER+ cases with abundance of an HTA 1.0 probe that has yet to be annotated. In Fig 4d, an intronic SNP in ZMIZ1 with tumor- and receptor-type specific effect on expression of HOXA6.