Table 2. Results of fQTL analysis applied to all breast tumor and adjacent normal samples.
| Tissue source | dbSNP ID | Context | SNP position | Pathway (GO MF) | Risk beta | FDR |
|---|---|---|---|---|---|---|
| Normal | ||||||
| rs12662670 | CCDC170 (intronic) | 6p25 | Small GTPase binding | -4.3 | 0.048 | |
| ER+ | ||||||
| rs6762644 | ITPR1 (intronic) | 3p26.1 | Phospholipase activity | 4.3 | 0.075 | |
| ER- | ||||||
| rs2823093 | intergenic | 21q21.1 | Oxidoreductase activity | 4.52 | 0.03 | |
| rs17529111 | intergenic | 6q14 | Hydrolase activity | 4.41 | 0.06 | |
| Neuropeptide hormone activity | 5.09 | 0.006 | ||||
| Sialyltransferase activity | 4.46 | 0.052 | ||||
| rs17530068 | intergenic | 6q14 | Hydrolase activity | 4.39 | 0.066 | |
| Sialyltransferase activity | 4.53 | 0.039 | ||||
| Nucleotide kinase activity | 4.52 | 0.041 |