Table 1. Novel IBD-associated loci.
| Rsid | Chr | Position bp | Left - right Mb | Risk Allele | Non - risk Allele | Risk Allele Frequency in 1000 Genomes CEU+GBR | PMeta | OR | 95% CI | Phenotype | Implicated gene |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs34687326 | 1 | 159799910 | 159.80 - 159.80 | G | A | 0.900 | 1.06 × 10-08 | 1.18 | 1.12 - 1.24 | CD | SLAMF8 |
| rs59043219 | 1 | 209970610 | 209.97 - 210.02 | A | G | 0.379 | 1.09 × 10-08 | 1.08 | 1.05 - 1.10 | IBD | - |
| rs6740847 | 2 | 182308352 | 182.31 - 182.33 | A | G | 0.508 | 1.22 × 10-13 | 1.10 | 1.07 - 1.12 | IBD | ITGA4 |
| rs144344067 | 2 | 187576378 | 187.50 - 187.68 | A | AT | 0.895 | 1.29 × 10-08 | 1.12 | 1.08 - 1.16 | IBD | - |
| rs1811711 | 2 | 228670476 | 228.67 - 228.67 | C | G | 0.826 | 6.09 × 10-09 | 1.14 | 1.10 - 1.18 | UC | - |
| rs76527535 | 2 | 242484701 | 242.47 - 242.49 | C | T | 0.745 | 2.87 × 10-08 | 1.09 | 1.06 - 1.12 | IBD | - |
| rs2581828 | 3 | 53133149 | 53.10 - 53.17 | C | G | 0.597 | 6.46 × 10-09 | 1.10 | 1.07 - 1.13 | CD | - |
| rs2593855 | 3 | 71175495 | 71.16 - 71.19 | C | T | 0.663 | 2.54 × 10-09 | 1.09 | 1.06 - 1.11 | IBD | - |
| rs503734 | 3 | 101023748 | 100.91 - 101.27 | A | G | 0.513 | 2.67 × 10-08 | 1.07 | 1.05 - 1.10 | IBD | - |
| rs56116661 | 3 | 188401160 | 188.40 - 188.40 | C | T | 0.795 | 5.67 × 10-10 | 1.14 | 1.10 - 1.18 | CD | - |
| rs11734570 | 4 | 38588453 | 38.58 - 38.59 | A | G | 0.368 | 4.80 × 10-08 | 1.07 | 1.05 - 1.10 | IBD | - |
| rs17656349 | 5 | 149605994 | 149.59 - 149.63 | T | C | 0.466 | 1.54 × 10-08 | 1.09 | 1.06 - 1.13 | UC | - |
| rs113986290 | 6 | 19781009 | 19.72 - 19.83 | C | T | 0.989 | 7.59 × 10-09 | 1.36 | 1.25 - 1.46 | UC | - |
| rs67289879 | 6 | 42007403 | 42.00 - 42.01 | T | C | 0.179 | 3.04 × 10-08 | 1.09 | 1.06 - 1.13 | IBD | - |
| rs11768365 | 7 | 6545188 | 6.50 - 6.55 | A | G | 0.816 | 3.88 × 10-08 | 1.09 | 1.06 - 1.12 | IBD | - |
| rs149169037 | 7 | 20577298 | 20.58 - 20.58 | G | A | 0.895 | 3.26 × 10-08 | 1.14 | 1.10 - 1.19 | IBD | ITGB8 |
| rs243505 | 7 | 148435339 | 148.40 - 148.58 | A | G | 0.624 | 3.04 × 10-10 | 1.08 | 1.06 - 1.11 | IBD | - |
| rs7911117 | 10 | 27179596 | 27.16 - 27.18 | T | G | 0.871 | 1.84 × 10-08 | 1.14 | 1.10 - 1.19 | UC | - |
| rs111456533 | 10 | 126439381 | 126.32 - 126.55 | G | A | 0.829 | 1.18 × 10-09 | 1.11 | 1.08 - 1.14 | IBD | - |
| rs80244186 | 13 | 42917861 | 42.84 - 42.94 | C | T | 0.111 | 3.66 × 10-08 | 1.13 | 1.09 - 1.18 | CD | - |
| rs11548656 | 16 | 81916912 | 81.91 - 81.92 | A | G | 0.961 | 5.18 × 10-11 | 1.27 | 1.20 - 1.34 | IBD | PLCG2 |
| rs10492862 | 16 | 82867456 | 82.87 - 82.92 | A | C | 0.308 | 1.26 × 10-09 | 1.11 | 1.08 - 1.15 | CD | - |
| rs4256018 | 20 | 6093889 | 6.08 - 6.10 | G | T | 0.250 | 1.23 × 10-08 | 1.08 | 1.05 - 1.11 | IBD | - |
| rs138788 | 22 | 35729721 | 35.72 - 35.74 | A | G | 0.418 | 2.95 × 10-08 | 1.09 | 1.06 - 1.13 | UC | - |
| rs4821544 | 22 | 37258503 | 37.26 - 37.26 | C | T | 0.321 | 1.76 × 10-08 | 1.10 | 1.07 - 1.13 | CD | - |