Table 1. Characteristics of transgenic mouse lines expressing PHveClg.
| Line | Copy no. | PHveClg in serum, μg/ml | Body weight, g | Litter size |
|---|---|---|---|---|
| 6 | 1 | 1,820.5 ± 188.3 | 16.2 ± 1.8a (4) | 8.0 ± 1.9d |
| 22 | 4 | 258.0 ± 100.5 | 18.9 ± 2.3b (3) | 7.4 ± 1.9d |
| 32 | 20 | 742.9 ± 47.9 | 18.3 ± 1.6b,c (8) | 6.0 ± 1.0d |
| 33 | 3 | 1,283.0 ± 370.8 | 17.1 ± 1.2b,c (7) | 7.6 ± 1.7d |
| 37 | 50 | 5.0 ± 1.9 | 17.5 ± 1.6a,b,c (6) | 7.2 ± 1.3d |
| 45 | 2 | 1,180.1 ± 279.9 | 18.2 ± 1.6b,c (8) | 3.8 ± 2.2 |
| C57BL/6 | 0 | 1.2 ± 0.6 | 17.4 ± 1.5a,b,c (8) | 6.2 ± 1.3d |
Copy number was estimated by Southern blot analysis, and the amount of PHveClg in serum was measured by competitive ELISA with at least three transgenic offspring. Shown is the body weight of 8-week-old female mice, with the number of transgenic mice tested shown in parentheses. Litter size was measured for five litters. Means sharing the same superscript letter are not significantly different from each other at threshold P < 0.05.