Table 1. NKL homeobox gene expressions in hematopoiesis (GSE69239) and T-ALL (GSE26713).
| NKL gene | synonyms | HSC | LMPP | CLP | BCP | TCP (DN) | TCP (DP,SP) | T-ALL | chr. transl. |
|---|---|---|---|---|---|---|---|---|---|
| BARHL1 | |||||||||
| BARHL2 | |||||||||
| BARX1 | |||||||||
| BARX2 | |||||||||
| BSX | BSX1 | ||||||||
| DBX1 | |||||||||
| DBX2 | |||||||||
| DLX1 | X | ||||||||
| DLX2 | X | ||||||||
| DLX3 | X | ||||||||
| DLX4 | |||||||||
| DLX5 | |||||||||
| DLX6 | X | ||||||||
| EMX1 | |||||||||
| EMX2 | |||||||||
| EN1 | |||||||||
| EN2 | |||||||||
| HHEX | PRHX | X | X | X | X | X | X | ||
| HLX | HLX1, HB24 | X | X | X | X | X | X | ||
| HMX1 | NKX5-3 | ||||||||
| HMX2 | NKX5-2 | ||||||||
| HMX3 | NKX5-1 | ||||||||
| LBX1 | X | ||||||||
| LBX2 | |||||||||
| MSX1 | X | X | X | ||||||
| MSX2 | X | ||||||||
| NANOG | X | ||||||||
| NKX1-1 | X | ||||||||
| NKX1-2 | |||||||||
| NKX2-1 | TITF1, TTF1 | X | X | ||||||
| NKX2-2 | X | X | |||||||
| NKX2-3 | X | X | |||||||
| NKX2-4 | |||||||||
| NKX2-5 | CSX | X | X | ||||||
| NKX2-6 | |||||||||
| NKX2-8 | |||||||||
| NKX3-1 | BAPX2 | X | X | X | |||||
| NKX3-2 | BAPX1 | X | |||||||
| NKX6-1 | |||||||||
| NKX6-2 | |||||||||
| NKX6-3 | X | X | |||||||
| NOTO | |||||||||
| TLX1 | HOX11 | X | X | ||||||
| TLX2 | HOX11L1 | X | X | ||||||
| TLX3 | HOX11L2 | X | X | ||||||
| VAX1 | |||||||||
| VAX2 | |||||||||
| VENTX | VENTX2 | X | |||||||
| 48 | 4 | 3 | 3 | 4 | 5 | 0 | 20 | 5 |
Significant transcript levels in the corresponding hematopoietic cell type are indicated by a cross and by grey background. Aberrantly overexpressed genes in T-ALL subsets are indicated by bold crosses. Genes involved in chromosomal aberrations in T-ALL are indicated by underlined crosses. HSPC: hematopoietic stem and progenitor cells, LMPP: lymphoid and myeloid progenitor, CLP: common lymphoid progenitor, BCP: B-cell progenitor, TCP(DN): T-cell progenitor (combined double negative T-cell progenitors), TCP(DP,SP): combined double positive and single positive T-cell progenitors.