Fig 1. Global transcriptional profiling of V. cholerae in response to hydrogen peroxide.

Wild type V. cholerae were grown in AKI medium [37] without shaking for 4 hrs. One set of cultures were then exposed to 0.5 mM H₂O₂ for 30 min. RNA was extracted and then subjected to RNA sequencing analysis. A. Chromosomal location of differentially expressed genes. The map was constructed using the Circos program [43]. Fold-changes of genes upregulated by H₂O₂ are labeled in black and downregulated labeled in blue. B. Highly induced V. cholerae genes by H₂O₂.