Fig 6. Nrf2 is requiered for full bone accrual in the female skeleton but unnecessary, and even detrimental, in the male skeleton.

μCT analysis of cancellous bone microarchitecture in L5 vertebrae in 3-month-old mice (A) and in 15-month-old mice (B). Bars represent means ± SD, n = 7–8 or 11–15 mice/ group, respectively. * p<0.05 versus respective WT by two-way ANOVA, followed by pairwise multiple comparisons using Tukey method. Representative images of vertebrae from young and old female and male Nrf2 KO and wild type littermate controls are shown in (C).