. Author manuscript; available in PMC: 2017 Jul 9.

Published in final edited form as: Nat Genet. 2017 Jan 9;49(2):186–192. doi: 10.1038/ng.3761

Table 1. Burden of rare, predicted damaging (CADD ≥ 21) coding variation in IBD gene sets.

Gene set	Constituents	Phenotype	P-value
*NOD2*	NOD2	CD	4.00 x 10^-07
Other IBD genes implicated by causal coding or eQTL variants (genes in brackets had zero contributing rare variants)	CARD9, FCGR2A, IFIH1, IL23R, MST1, (SMAD3), TYK2, (IL10), IL18RAP, (ITGAL), NXPE1, TNFSF8	UC	0.46153
	ATG16L1, CARD9, CD6, FCGR2A, FUT2, IL23R, MST1, (NOD2), PTPN22, (SMAD3), TYK2, ERAP2, (IL10), IL18RAP, (IL2RA), (SP140), TNFSF8	CD	0.00448
	CARD9, FCGR2A, IL23R, MST1, (SMAD3), TYK2, (IL10), IL18RAP, TNFSF8	IBD	0.00261
Other IBD GWAS genes	Genes implicated by two or more candidate gene approaches in Jostins et al (2012)	UC	0.95123
		CD	0.94382
		IBD	0.93070