Table 2. Genotyping and allele frequency of AURKA single nucleotide polymorphism in oral cancer and normal controls.
| Variable | Controls N = 1200(%) | Patients N = 876 (%) | AOR (95% CI) | p value |
|---|---|---|---|---|
| rs1047972 | ||||
| CC | 925 (77.1%) | 668 (76.3%) | 1.00 | |
| TC | 261 (21.8%) | 190 (21.7%) | 0.93 (0.70–1.23) | p = 0.60 |
| TT | 14 (1.1%) | 18 (2.0%) | 1.95 (0.74–5.13) | p = 0.18 |
| TC+TT | 275 (22.9%) | 208 (23.7%) | 0.97 (0.74–1.27) | p = 0.84 |
| C allele | 2111 (88.0%) | 1526 (87.1%) | 1.00 | |
| T allele | 289 (12.0%) | 226 (12.9%) | 1.02 (0.80–1.31) | p = 0.87 |
| rs2273535 | ||||
| TT | 583 (48.6%) | 404 (46.1%) | 1.00 | |
| AT | 490 (40.8%) | 368 (42.0%) | 1.16 (0.91–1.48) | p = 0.25 |
| AA | 127 (10.6%) | 104 (11.9%) | 1.03 (0.70–1.51) | p = 0.88 |
| AT+AA | 617 (51.4%) | 472 (53.9%) | 1.13 (0.90–1.42) | p = 0.31 |
| T allele | 1656 (69.0%) | 1176 (67.1%) | 1.00 | |
| A allele | 774 (31.0%) | 576 (32.9%) | 1.06 (0.89–1.26) | p = 0.50 |
| rs2064863 | ||||
| TT | 827 (68.9%) | 590 (67.4%) | 1.00 | |
| GT | 338 (28.2%) | 252 (28.8%) | 1.01 (0.79–1.31) | p = 0.92 |
| GG | 35 (2.9%) | 34 (3.8%) | 1.21 (0.64–2.30) | p = 0.55 |
| GT+GG | 373 (31.1%) | 286 (32.6%) | 1.03 (0.81–1.32) | p = 0.80 |
| T allele | 1992 (83.0%) | 1432 (81.7%) | 1.00 | |
| G allele | 408 (17.0%) | 320 (18.3%) | 1.05(0.85–1.29) | p = 0.67 |
| rs6024836 | ||||
| AA | 525 (43.8%) | 352 (40.2%) | 1.00 | |
| AG | 530 (44.2%) | 397 (45.3%) | 1.15 (0.90–1.47) | p = 0.26 |
| GG | 145 (12.0%) | 127 (14.5%) | 1.19(0.83–1.70) | p = 0.36 |
| AG+GG | 675 (56.2%) | 524 (59.8%) | 0.86 (0.68–1.09) | p = 0.22 |
| A allele | 1580 (65.8%) | 1101 (62.8%) | 1.00 | |
| G allele | 820 (34.2%) | 651 (37.2%) | 1.11 (0.94–1.31) | p = 0.24 |