Table 2.
Myeloperoxidase activity following Trinitrobenzene sulfonic acid treatment.
| Naïve | NMS‡ | |
|---|---|---|
| Baseline (n = 3) | 0.852 ± 0.20 | 0.606 ± 0.25 |
| 1d post (n = 4) | 6.43 ± 1.64 | 8.06 ± 0.77 |
| 4d post (n = 4) | 4.75 ± 1.81 | 12.12 ± 3.81## |
Myeloperoxidase (MPO) activity (expressed as U mg−1 tissue weight) was measured in distal colon from naïve and NMS mice prior to (baseline) and following intracolonic instillation of 5 mg trinitrobenzene sulfonic acid (TNBS). Treatment with TNBS significantly increased MPO levels in both groups (p = 0.0071, two-way ANOVA). Naïve MPO levels peaked at 1d post-TNBS, while NMS MPO levels continued to increase at 4d post-TNBS. ##p < 0.01 vs. baseline, Bonferroni posttest. ‡ denotes NMS (neonatal maternal separation) mice that were separated from postnatal day 1–14.