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The dual FAAH and MAGL inhibitor SA-57 ameliorates allodynia and inflammation in the carrageenan inflammatory pain model. SA-57 (A) reverses carrageenan-induced allodynia, and (B) partially reverses carrageenan-induced edema. Tests were conducted 2 hr after i.p. administration of SA-57 produces reversal from allodynia. Filled symbols indicate at least p < 0.05 vs. vehicle. Data reflect mean ± SEM, n=6 mice per group.
