Figure 5.
Repeated administration of 1.79 mg/kg SA-57 and 1.12 mg/kg morphine retains its anti-allodynic and anti-thermal hyperalgesic effects. Both acute and repeated administration of the combination of SA-57 and morphine reverse CCI-induced A) allodynia and B) thermal hyperalgesia. *** p<0.0001, * p < 0.05 vs. sham - vehicle. Data reflect mean ± SEM, n=6 mice per group.