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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2016 Aug 5;15(10):2521–2529. doi: 10.1158/1535-7163.MCT-16-0258

Figure 2.

Figure 2

Dox-induced bitransgenic C/KR mice develop lung tumors. A, H&E stained sections showing C/KR bitransgenic mice developed areas of hyperplastic lesions and early tumors after one month Dox induction. B, lung sections of a C/KR mouse induced with Dox for 4 months. Left, an H&E stained lung section showing lung with desmoplastic tumors. Right, tumor cells were stained positive of nuclear TTF1. C, lung sections of a C/KR mouse induced with Dox for 5 months. Right, H&E stained lung section with extensive tumors and desmoplasia. Right, cytokeratin stain confirmed invasive lung tumor.

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