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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2016 Aug 5;15(10):2521–2529. doi: 10.1158/1535-7163.MCT-16-0258

Figure 3.

Figure 3

KIF5B-RET expression is required to maintain lung tumors. A, C/KR mice developed MRI-detectable lung adenocarcinoma after Dox induction for 5 months. MRI images of representative tumor bearing mouse prior to and one month after Dox withdrawal. The graph shows comparison of MRI-detectable lung tumor burden prior to and post Dox withdrawal. Each line represents an individual mouse (n = 7). VOI, Volume of interest. B, H&E stained tissue section from lung of a mouse after Dox withdrawal (left). Lung tissue image from Genie® v1 histology pattern recognition software (Aperio) analysis (middle). Lung tumor burden was analyzed from H&E stained lung tissues (right) (n = 5 in each group). AOI, areas of interest. White, not lung tissue, area excluded; pink, background; blue, normal; purple: hyperplasia/neoplasia including some areas of normal bronchial epithelia (21). C, comparison of pRET and RET protein in the lungs of C/KR mice induced with Dox (prior to Dox withdrawal) and 1 month post Dox withdrawal. W, wildtype mouse.

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