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. 2004 Nov 2;101(46):16345–16350. doi: 10.1073/pnas.0407355101

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Copyright © 2004, The National Academy of Sciences

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Fig. 2. — CRF increases tPA activity in the amygdala in brain slices by means of the CRF-R1 receptor. CRF caused a significant up-regulation of tPA in the central and medial amygdala in comparison with the slice perfused with RS only (dark lytic areas in B vs. A). This up-regulation was inhibited by the CRF-R1 antagonist, antalarmin (ALM, C), but not the CRF-R2 antagonist Antisauvagine 30 (ASV, D). Slices perfused with CRF with addition of ALM or ASV vehicle (corresponding to C and D) are not shown. Round dark area with bright halo in D is an artifact caused by an air bubble in the overlay gel. (E) Quantification of changes shown in A-D (n = 5 slices per group) in relation to the mean area of lysis in slices perfused with RS only. ^**, P < 0.05.